Serine/threonine-protein kinase SIK3 (EC 2.7.11.1) (Salt-inducible kinase 3) (SIK-3) (Serine/threonine-protein kinase QSK)
1_MAAAA 6_ ASGAG 11_ GAAGA 16_ GTGGA 21_ GPAGR 26_ LLPPP 31_ APGSP 36_ AAPAA 41_ VSPAA 46_ GQPRP 51_ PAPAS 56_ RGPMP 61_ ARIGY 66_ YEIDR 71_ TIGKG 76_ NFAVV 81_ KRATH 86_ LVTKA 91_ KVAIK 96_ IIDKT 101_ QLDEE 106_ NLKKI 111_ FREVQ 116_ IMKML 121_ CHPHI 126_ IRLYQ 131_ VMETE 136_ RMIYL 141_ VTEYA 146_ SGGEI 151_ FDHLV 156_ AHGRM 161_ AEKEA 166_ RRKFK 171_ QIVTA 176_ VYFCH 181_ CRNIV 186_ HRDLK 191_ AENLL 196_ LDANL 201_ NIKIA 206_ DFGFS 211_ NLFTP 216_ GQLLK 221_ TWCGS 226_ PPYAA 231_ PELFE 236_ GKEYD 241_ GPKVD 246_ IWSLG 251_ VVLYV 256_ LVCGA 261_ LPFDG 266_ STLQN 271_ LRARV 276_ LSGKF 281_ RIPFF 286_ MSTEC 291_ EHLIR 296_ HMLVL 301_ DPNKR 306_ LSMEQ 311_ ICKHK 316_ WMKLG 321_ DADPN 326_ FDRLI 331_ AECQQ 336_ LKEER 341_ QVDPL 346_ NEDVL 351_ LAMED 356_ MGLDK 361_ EQTLQ 366_ SLRSD 371_ AYDHY 376_ SAIYS 381_ LLCDR 386_ HKRHK 391_ TLRLG 396_ ALPSM 401_ PRALA 406_ FQAPV 411_ NIQAE 416_ QAGTA 421_ MNISV 426_ PQVQL 431_ INPEN 436_ QIVEP 441_ DGTLN 446_ LDSDE 451_ GEEPS 456_ PEALV 461_ RYLSM 466_ RRHTV 471_ GVADP 476_ RTEVM 481_ EDLQK 486_ LLPGF 491_ PGVNP 496_ QAPFL 501_ QVAPN 506_ VNFMH 511_ NLLPM 516_ QNLQP 521_ TGQLE 526_ YKEQS 531_ LLQPP 536_ TLQLL 541_ NGMGP 546_ LGRRA 551_ SDGGA 556_ NIQLH 561_ AQQLL 566_ KRPRG 571_ PSPLV 576_ TMTPA 581_ VPAVT 586_ PVDEE 591_ SSDGE 596_ PDQEA 601_ VQSST 606_ YKDSN 611_ TLHLP 616_ TERFS 621_ PVRRF 626_ SDGAA 631_ SIQAF 636_ KAHLE 641_ KMGNN 646_ SSIKQ 651_ LQQEC 656_ EQLQK 661_ MYGGQ 666_ IDERT 671_ LEKTQ 676_ QQHML 681_ YQQEQ 686_ HHQIL 691_ QQQIQ 696_ DSICP 701_ PQPSP 706_ PLQAA 711_ CENQP 716_ ALLTH 721_ QLQRL 726_ RIQPS 731_ SPPPN 736_ HPNNH 741_ LFRQP 746_ SNSPP 751_ PMSSA 756_ MIQPH 761_ GAASS 766_ SQFQG 771_ LPSRS 776_ AIFQQ 781_ QPENC 786_ SSPPN 791_ VALTC 796_ LGMQQ 801_ PAQSQ 806_ QVTIQ 811_ VQEPV 816_ DMLSN 821_ MPGTA 826_ AGSSG 831_ RGISI 836_ SPSAG 841_ QMQMQ 846_ HRTNL 851_ MATLS 856_ YGHRP 861_ LSKQL 866_ SADSA 871_ EAHSL 876_ NVNRF 881_ SPANY 886_ DQAHL 891_ HPHLF 896_ SDQSR 901_ GSPSS 906_ YSPST 911_ GVGFS 916_ PTQAL 921_ KVPPL 926_ DQFPT 931_ FPPSA 936_ HQQPP 941_ HYTTS 946_ ALQQA 951_ LLSPT 956_ PPDYT 961_ RHQQV 966_ PHILQ 971_ GLLSP 976_ RHSLT 981_ GHSDI 986_ RLPPT 991_ EFAQL 996_ IKRQQ 1001_ QQRQQ 1006_ QQQQQ 1011_ QQQEY 1016_ QELFR 1021_ HMNQG 1026_ DAGSL 1031_ APSLG 1036_ GQSMT 1041_ ERQAL 1046_ SYQNA 1051_ DSYHH 1056_ HTSPQ 1061_ HLLQI 1066_ RAQEC 1071_ VSQAS 1076_ SPTPP 1081_ HGYAH 1086_ QPALM 1091_ HSESM 1096_ EEDCS 1101_ CEGAK 1106_ DGFQD 1111_ SKSSS 1116_ TLTKG 1121_ CHDSP 1126_ LLLST 1131_ GGPGD 1136_ PESLL 1141_ GTVSH 1146_ AQELG 1151_ IHPYG 1156_ HQPTA 1161_ AFSKN 1166_ KVPSR 1171_ EPVIG 1176_ NCMDR 1181_ SSPGQ 1186_ AVELP 1191_ DHNGL 1196_ GYPAR 1201_ PSVHE 1206_ HHRPR 1211_ ALQRH 1216_ HTIQN 1221_ SDDAY 1226_ VQLDN 1231_ LPGMS 1236_ LVAGK 1241_ ALSSA 1246_ RMSDA 1251_ VLSQS 1256_ SLMGS 1261_ QQFQD 1266_ GENEE 1271_ CGASL 1276_ GGHEH 1281_ PDLSD 1286_ GSQHL 1291_ NSSCY 1296_ PSTCI 1301_ TDILL 1306_ SYKHP 1311_ EVSFS 1316_MEQAG
1: Positive regulator of mTOR signaling that functions by triggering the degradation of DEPTOR, an mTOR inhibitor. Involved in the dynamic regulation of mTOR signaling in chondrocyte differentiation during skeletogenesis (PubMed:30232230). Negatively regulates cAMP signaling pathway possibly by acting on CRTC2/TORC2 and CRTC3/TORC3 (Probable). Prevents HDAC4 translocation to the nucleus (By similarity)