Ubiquitin carboxyl-terminal hydrolase 20 (EC 3.4.19.12) (Deubiquitinating enzyme 20) (Ubiquitin thioesterase 20) (Ubiquitin-specific-processing protease 20) (VHL-interacting deubiquitinating enzyme 2) (hVDU2)
1_MGDSR 6_ DLCPH 11_ LDSIG 16_ EVTKE 21_ DLLLK 26_ SKGTC 31_ QSCGV 36_ TGPNL 41_ WACLQ 46_ VACPY 51_ VGCGE 56_ SFADH 61_ STIHA 66_ QAKKH 71_ NLTVN 76_ LTTFR 81_ LWCYA 86_ CEKEV 91_ FLEQR 96_ LAAPL 101_ LGSSS 106_ KFSEQ 111_ DSPPP 116_ SHPLK 121_ AVPIA 126_ VADEG 131_ ESESE 136_ DDDLK 141_ PRGLT 146_ GMKNL 151_ GNSCY 156_ MNAAL 161_ QALSN 166_ CPPLT 171_ QFFLE 176_ CGGLV 181_ RTDKK 186_ PALCK 191_ SYQKL 196_ VSEVW 201_ HKKRP 206_ SYVVP 211_ TSLSH 216_ GIKLV 221_ NPMFR 226_ GYAQQ 231_ DTQEF 236_ LRCLM 241_ DQLHE 246_ ELKEP 251_ VVATV 256_ ALTEA 261_ RDSDS 266_ SDTDE 271_ KREGD 276_ RSPSE 281_ DEFLS 286_ CDSSS 291_ DRGEG 296_ DGQGR 301_ GGGSS 306_ QAETE 311_ LLIPD 316_ EAGRA 321_ ISEKE 326_ RMKDR 331_ KFSWG 336_ QQRTN 341_ SEQVD 346_ EDADV 351_ DTAMA 356_ ALDDQ 361_ PAEAQ 366_ PPSPR 371_ SSSPC 376_ RTPEP 381_ DNDAH 386_ LRSSS 391_ RPCSP 396_ VHHHE 401_ GHAKL 406_ SSSPP 411_ RASPV 416_ RMAPS 421_ YVLKK 426_ AQVLS 431_ AGSRR 436_ RKEQR 441_ YRSVI 446_ SDIFD 451_ GSILS 456_ LVQCL 461_ TCDRV 466_ STTVE 471_ TFQDL 476_ SLPIP 481_ GKEDL 486_ AKLHS 491_ AIYQN 496_ VPAKP 501_ GACGD 506_ SYAAQ 511_ GWLAF 516_ IVEYI 521_ RRFVV 526_ SCTPS 531_ WFWGP 536_ VVTLE 541_ DCLAA 546_ FFAAD 551_ ELKGD 556_ NMYSC 561_ ERCKK 566_ LRNGV 571_ KYCKV 576_ LRLPE 581_ ILCIH 586_ LKRFR 591_ HEVMY 596_ SFKIN 601_ SHVSF 606_ PLEGL 611_ DLRPF 616_ LAKEC 621_ TSQIT 626_ TYDLL 631_ SVICH 636_ HGTAG 641_ SGHYI 646_ AYCQN 651_ VINGQ 656_ WYEFD 661_ DQYVT 666_ EVHET 671_ VVQNA 676_ EGYVL 681_ FYRKS 686_ SEEAM 691_ RERQQ 696_ VVSLA 701_ AMREP 706_ SLLRF 711_ YVSRE 716_ WLNKF 721_ NTFAE 726_ PGPIT 731_ NQTFL 736_ CSHGG 741_ IPPHK 746_ YHYID 751_ DLVVI 756_ LPQNV 761_ WEHLY 766_ NRFGG 771_ GPAVN 776_ HLYVC 781_ SICQV 786_ EIEAL 791_ AKRRR 796_ IEIDT 801_ FIKLN 806_ KAFQA 811_ EESPG 816_ VIYCI 821_ SMQWF 826_ REWEA 831_ FVKGK 836_ DNEPP 841_ GPIDN 846_ SRIAQ 851_ VKGSG 856_ HVQLK 861_ QGADY 866_ GQISE 871_ ETWTY 876_ LNSLY 881_ GGGPE 886_ IAIRQ 891_ SVAQP 896_ LGPEN 901_ LHGEQ 906_KIEAE
1: Deubiquitinating enzyme that plays a role in many cellular processes including autophagy, cellular antiviral response or membrane protein biogenesis (PubMed:27801882, PubMed:29487085). Attenuates TLR4-mediated NF-kappa-B signaling by cooperating with beta-arrestin-2/ARRB2 and inhibiting TRAF6 autoubiquitination (PubMed:26839314). Promotes cellular antiviral responses by deconjugating 'Lys-33' and 'Lys-48'-linked ubiquitination of STING1 leading to its stabilization (PubMed:27801882). Plays an essential role in autophagy induction by regulating the ULK1 stability through deubiquitination of ULK1 (PubMed:29487085). Acts as a positive regulator for NF-kappa-B activation by TNF-alpha through deubiquitinating 'Lys-48'-linked polyubiquitination of SQSTM1, leading to its increased stability (PubMed:32354117). Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2) (PubMed:19424180). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2 (PubMed:19424180). This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity (PubMed:15776016). Deubiquitinates MCL1, a pivotal member of the anti-apoptotic Bcl-2 protein family to regulate its stability (PubMed:35063767). Within the endoplasmic reticulum, participates with USP33 in the rescue of post-translationally targeted membrane proteins that are inappropriately ubiquitinated by the cytosolic protein quality control in the cytosol (PubMed:33792613)