Lysine-specific demethylase 2A (EC 1.14.11.27) (CXXC-type zinc finger protein 8) (F-box and leucine-rich repeat protein 11) (F-box protein FBL7) (F-box protein Lilina) (F-box/LRR-repeat protein 11) (JmjC domain-containing histone demethylation protein 1A) ([Histone-H3]-lysine-36 demethylase 1A)
1_MEPEE 6_ ERIRY 11_ SQRLR 16_ GTMRR 21_ RYEDD 26_ GISDD 31_ EIEGK 36_ RTFDL 41_ EEKLH 46_ TNKYN 51_ ANFVT 56_ FMEGK 61_ DFNVE 66_ YIQRG 71_ GLRDP 76_ LIFKN 81_ SDGLG 86_ IKMPD 91_ PDFTV 96_ NDVKM 101_ CVGSR 106_ RMVDV 111_ MDVNT 116_ QKGIE 121_ MTMAQ 126_ WTRYY 131_ ETPEE 136_ EREKL 141_ YNVIS 146_ LEFSH 151_ TRLEN 156_ MVQRP 161_ STVDF 166_ IDWVD 171_ NMWPR 176_ HLKES 181_ QTEST 186_ NAILE 191_ MQYPK 196_ VQKYC 201_ LMSVR 206_ GCYTD 211_ FHVDF 216_ GGTSV 221_ WYHIH 226_ QGGKV 231_ FWLIP 236_ PTAHN 241_ LELYE 246_ NWLLS 251_ GKQGD 256_ IFLGD 261_ RVSDC 266_ QRIEL 271_ KQGYT 276_ FVIPS 281_ GWIHA 286_ VYTPT 291_ DTLVF 296_ GGNFL 301_ HSFNI 306_ PMQLK 311_ IYNIE 316_ DRTRV 321_ PNKFR 326_ YPFYY 331_ EMCWY 336_ VLERY 341_ VYCIT 346_ NRSHL 351_ TKEFQ 356_ KESLS 361_ MDLEL 366_ NGLES 371_ GNGDE 376_ EAVDR 381_ EPRRL 386_ SSRRS 391_ VLTSP 396_ VANGV 401_ NLDYD 406_ GLGKT 411_ CRSLP 416_ SLKKT 421_ LAGDS 426_ SSDCS 431_ RGSHN 436_ GQVWD 441_ PQCAP 446_ RKDRQ 451_ VHLTH 456_ FELEG 461_ LRCLV 466_ DKLES 471_ LPLHK 476_ KCVPT 481_ GIEDE 486_ DALIA 491_ DVKIL 496_ LEELA 501_ NSDPK 506_ LALTG 511_ VPIVQ 516_ WPKRD 521_ KLKFP 526_ TRPKV 531_ RVPTI 536_ PITKP 541_ HTMKP 546_ APRLT 551_ PVRPA 556_ AASPI 561_ VSGAR 566_ RRRVR 571_ CRKCK 576_ ACVQG 581_ ECGVC 586_ HYCRD 591_ MKKFG 596_ GPGRM 601_ KQSCV 606_ LRQCL 611_ APRLP 616_ HSVTC 621_ SLCGE 626_ VDQNE 631_ ETQDF 636_ EKKLM 641_ ECCIC 646_ NEIVH 651_ PGCLQ 656_ MDGEG 661_ LLNEE 666_ LPNCW 671_ ECPKC 676_ YQEDS 681_ SEKAQ 686_ KRKME 691_ ESDEE 696_ AVQAK 701_ VLRPL 706_ RSCDE 711_ PLTPP 716_ PHSPT 721_ SMLQL 726_ IHDPV 731_ SPRGM 736_ VTRSS 741_ PGAGP 746_ SDHHS 751_ ASRDE 756_ RFKRR 761_ QLLRL 766_ QATER 771_ TMVRE 776_ KENNP 781_ SGKKE 786_ LSEVE 791_ KAKIR 796_ GSYLT 801_ VTLQR 806_ PTKEL 811_ HGTSI 816_ VPKLQ 821_ AITAS 826_ SANLR 831_ HSPRV 836_ LVQHC 841_ PARTP 846_ QRGDE 851_ EGLGG 856_ EEEEE 861_ EEEEE 866_ EDDSA 871_ EEGGA 876_ ARLNG 881_ RGSWA 886_ QDGDE 891_ SWMQR 896_ EVWMS 901_ VFRYL 906_ SRREL 911_ CECMR 916_ VCKTW 921_ YKWCC 926_ DKRLW 931_ TKIDL 936_ SRCKA 941_ IVPQA 946_ LSGII 951_ KRQPV 956_ SLDLS 961_ WTNIS 966_ KKQLT 971_ WLVNR 976_ LPGLK 981_ DLLLA 986_ GCSWS 991_ AVSAL 996_ STSSC 1001_ PLLRT 1006_ LDLRW 1011_ AVGIK 1016_ DPQIR 1021_ DLLTP 1026_ PADKP 1031_ GQDNR 1036_ SKLRN 1041_ MTDFR 1046_ LAGLD 1051_ ITDAT 1056_ LRLII 1061_ RHMPL 1066_ LSRLD 1071_ LSHCS 1076_ HLTDQ 1081_ SSNLL 1086_ TAVGS 1091_ STRYS 1096_ LTELN 1101_ MAGCN 1106_ KLTDQ 1111_ TLIYL 1116_ RRIAN 1121_ VTLID 1126_ LRGCK 1131_ QITRK 1136_ ACEHF 1141_ ISDLS 1146_ INSLY 1151_ CLSDE 1156_KLIQK
1: Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. Regulates circadian gene expression by repressing the transcriptional activator activity of CLOCK-BMAL1 heterodimer and RORA in a catalytically-independent manner (PubMed:26037310)