Exosome complex exonuclease RRP44 (EC 3.1.13.-) (EC 3.1.26.-) (Protein DIS3 homolog) (Ribosomal RNA-processing protein 44)
1_MLKSK 6_ TFLKK 11_ TRAGG 16_ VMKIV 21_ REHYL 26_ RDDIG 31_ CGAPG 36_ CAACG 41_ GAHEG 46_ PALEP 51_ QPQDP 56_ ASSVC 61_ PQPHY 66_ LLPDT 71_ NVLLH 76_ QIDVL 81_ EDPAI 86_ RNVIV 91_ LQTVL 96_ QEVRN 101_ RSAPV 106_ YKRIR 111_ DVTNN 116_ QEKHF 121_ YTFTN 126_ EHHRE 131_ TYVEQ 136_ EQGEN 141_ ANDRN 146_ DRAIR 151_ VAAKW 156_ YNEHL 161_ KKMSA 166_ DNQLQ 171_ VIFIT 176_ NDRRN 181_ KEKAI 186_ EEGIP 191_ AFTCE 196_ EYVKS 201_ LTANP 206_ ELIDR 211_ LACLS 216_ EEGNE 221_ IESGK 226_ IIFSE 231_ HLPLS 236_ KLQQG 241_ IKSGT 246_ YLQGT 251_ FRASR 256_ ENYLE 261_ ATVWI 266_ HGDNE 271_ ENKEI 276_ ILQGL 281_ KHLNR 286_ AVHED 291_ IVAVE 296_ LLPKS 301_ QWVAP 306_ SSVVL 311_ HDEGQ 316_ NEEDV 321_ EKEEE 326_ TERML 331_ KTAVS 336_ EKMLK 341_ PTGRV 346_ VGIIK 351_ RNWRP 356_ YCGML 361_ SKSDI 366_ KESRR 371_ HLFTP 376_ ADKRI 381_ PRIRI 386_ ETRQA 391_ STLEG 396_ RRIIV 401_ AIDGW 406_ PRNSR 411_ YPNGH 416_ FVRNL 421_ GDVGE 426_ KETET 431_ EVLLL 436_ EHDVP 441_ HQPFS 446_ QAVLS 451_ FLPKM 456_ PWSIT 461_ EKDMK 466_ NREDL 471_ RHLCI 476_ CSVDP 481_ PGCTD 486_ IDDAL 491_ HCREL 496_ ENGNL 501_ EVGVH 506_ IADVS 511_ HFIRP 516_ GNALD 521_ QESAR 526_ RGTTV 531_ YLCEK 536_ RIDMV 541_ PELLS 546_ SNLCS 551_ LKCDV 556_ DRLAF 561_ SCIWE 566_ MNHNA 571_ EILKT 576_ KFTKS 581_ VINSK 586_ ASLTY 591_ AEAQL 596_ RIDSA 601_ NMNDD 606_ ITTSL 611_ RGLNK 616_ LAKIL 621_ KKRRI 626_ EKGAL 631_ TLSSP 636_ EVRFH 641_ MDSET 646_ HDPID 651_ LQTKE 656_ LRETN 661_ SMVEE 666_ FMLLA 671_ NISVA 676_ KKIHE 681_ EFSEH 686_ ALLRK 691_ HPAPP 696_ PSNYE 701_ ILVKA 706_ ARSRN 711_ LEIKT 716_ DTAKS 721_ LAESL 726_ DQAES 731_ PTFPY 736_ LNTLL 741_ RILAT 746_ RCMMQ 751_ AVYFC 756_ SGMDN 761_ DFHHY 766_ GLASP 771_ IYTHF 776_ TSPIR 781_ RYADV 786_ IVHRL 791_ LAVAI 796_ GADCT 801_ YPELT 806_ DKHKL 811_ ADICK 816_ NLNFR 821_ HKMAQ 826_ YAQRA 831_ SVAFH 836_ TQLFF 841_ KSKGI 846_ VSEEA 851_ YILFV 856_ RKNAI 861_ VVLIP 866_ KYGLE 871_ GTVFF 876_ EEKDK 881_ PNPQL 886_ IYDDE 891_ IPSLK 896_ IEDTV 901_ FHVFD 906_ KVKVK 911_ IMLDS 916_ SNLQH 921_ QKIRM 926_ SLVEP 931_ QIPGI 936_ SIPTD 941_ TSNMD 946_ LNGPK 951_KKKMK
1: Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities