Fanconi-associated nuclease 1 (EC 3.1.21.-) (EC 3.1.4.1) (FANCD2/FANCI-associated nuclease 1) (hFAN1) (Myotubularin-related protein 15)
1_MMSEG 6_ KPPDK 11_ KRPRR 16_ SLSIS 21_ KNKKK 26_ ASNSI 31_ ISCFN 36_ NAPPA 41_ KLACP 46_ VCSKM 51_ VPRYD 56_ LNRHL 61_ DEMCA 66_ NNDFV 71_ QVDPG 76_ QVGLI 81_ NSNVS 86_ MVDLT 91_ SVTLE 96_ DVTPK 101_ KSPPP 106_ KTNLT 111_ PGQSD 116_ SAKRE 121_ VKQKI 126_ SPYFK 131_ SNDVV 136_ CKNQD 141_ ELRNR 146_ SVKVI 151_ CLGSL 156_ ASKLS 161_ RKYVK 166_ AKKSI 171_ DKDEE 176_ FAGSS 181_ PQSSK 186_ STVVK 191_ SLIDN 196_ SSEIE 201_ DEDQI 206_ LENSS 211_ QKENV 216_ FKCDS 221_ LKEEC 226_ IPEHM 231_ VRGSK 236_ IMEAE 241_ SQKAT 246_ RECEK 251_ SALTP 256_ GFSDN 261_ AIMLF 266_ SPDFT 271_ LRNTL 276_ KSTSE 281_ DSLVK 286_ QECIK 291_ EVVEK 296_ REACH 301_ CEEVK 306_ MTVAS 311_ EAKIQ 316_ LSDSE 321_ AKSHS 326_ SADDA 331_ SAWSN 336_ IQEAP 341_ LQDDS 346_ CLNND 351_ IPHSI 356_ PLEQG 361_ SSCNG 366_ PGQTT 371_ GHPYY 376_ LRSFL 381_ VVLKT 386_ VLENE 391_ DDMLL 396_ FDEQE 401_ KGIVT 406_ KFYQL 411_ SATGQ 416_ KLYVR 421_ LFQRK 426_ LSWIK 431_ MTKLE 436_ YEEIA 441_ LDLTP 446_ VIEEL 451_ TNAGF 456_ LQTES 461_ ELQEL 466_ SEVLE 471_ LLSAP 476_ ELKSL 481_ AKTFH 486_ LVNPN 491_ GQKQQ 496_ LVDAF 501_ LKLAK 506_ QRSVC 511_ TWGKN 516_ KPGIG 521_ AVILK 526_ RAKAL 531_ AGQSV 536_ RICKG 541_ PRAVF 546_ SRILL 551_ LFSLT 556_ DSMED 561_ EDAAC 566_ GGQGQ 571_ LSTVL 576_ LVNLG 581_ RMEFP 586_ SYTIN 591_ RKTHI 596_ FQDRD 601_ DLIRY 606_ AAATH 611_ MLSDI 616_ SSAMA 621_ NGNWE 626_ EAKEL 631_ AQCAK 636_ RDWNR 641_ LKNHP 646_ SLRCH 651_ EDLPL 656_ FLRCF 661_ TVGWI 666_ YTRIL 671_ SRFVE 676_ ILQRL 681_ HMYEE 686_ AVREL 691_ ESLLS 696_ QRIYC 701_ PDSRG 706_ RWWDR 711_ LALNL 716_ HQHLK 721_ RLEPT 726_ IKCIT 731_ EGLAD 736_ PEVRT 741_ GHRLS 746_ LYQRA 751_ VRLRE 756_ SPSCK 761_ KFKHL 766_ FQQLP 771_ EMAVQ 776_ DVKHV 781_ TITGR 786_ LCPQR 791_ GMCKS 796_ VFVME 801_ AGEAA 806_ DPTTV 811_ LCSVE 816_ ELALA 821_ HYRRS 826_ GFDQG 831_ IHGEG 836_ STFST 841_ LYGLL 846_ LWDII 851_ FMDGI 856_ PDVFR 861_ NACQA 866_ FPLDL 871_ CTDSF 876_ FTSRR 881_ PALEA 886_ RLQLI 891_ HDAPE 896_ ESLRA 901_ WVAAT 906_ WHEQE 911_ GRVAS 916_ LVSWD 921_ RFTSL 926_ QQAQD 931_ LVSCL 936_ GGPVL 941_ SGVCR 946_ HLAAD 951_ FRHCR 956_ GGLPD 961_ LVVWN 966_ SQSRH 971_ FKLVE 976_ VKGPN 981_ DRLSH 986_ KQMIW 991_ LAELQ 996_ KLGAE 1001_ VEVCH 1006_ VVAVG 1011_AKSQS
1: Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates (PubMed:20603015, PubMed:20603016, PubMed:20603073, PubMed:20671156, PubMed:24981866, PubMed:25430771). Not involved in DNA double-strand breaks resection (PubMed:20603015, PubMed:20603016). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL (PubMed:25430771). Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap (PubMed:25430771). Also has endonuclease activity toward 5'-flaps (PubMed:20603015, PubMed:20603016, PubMed:24981866)