Kelch-like protein 20 (Kelch-like ECT2-interacting protein) (Kelch-like protein X)
1_MEGKP 6_ MRRCT 11_ NIRPG 16_ ETGMD 21_ VTSRC 26_ TLGDP 31_ NKLPE 36_ GVPQP 41_ ARMPY 46_ ISDKH 51_ PRQTL 56_ EVINL 61_ LRKHR 66_ ELCDV 71_ VLVVG 76_ AKKIY 81_ AHRVI 86_ LSACS 91_ PYFRA 96_ MFTGE 101_ LAESR 106_ QTEVV 111_ IRDID 116_ ERAME 121_ LLIDF 126_ AYTSQ 131_ ITVEE 136_ GNVQT 141_ LLPAA 146_ CLLQL 151_ AEIQE 156_ ACCEF 161_ LKRQL 166_ DPSNC 171_ LGIRA 176_ FADTH 181_ SCREL 186_ LRIAD 191_ KFTQH 196_ NFQEV 201_ MESEE 206_ FMLLP 211_ ANQLI 216_ DIISS 221_ DELNV 226_ RSEEQ 231_ VFNAV 236_ MAWVK 241_ YSIQE 246_ RRPQL 251_ PQVLQ 256_ HVRLP 261_ LLSPK 266_ FLVGT 271_ VGSDP 276_ LIKSD 281_ EECRD 286_ LVDEA 291_ KNYLL 296_ LPQER 301_ PLMQG 306_ PRTRP 311_ RKPIR 316_ CGEVL 321_ FAVGG 326_ WCSGD 331_ AISSV 336_ ERYDP 341_ QTNEW 346_ RMVAS 351_ MSKRR 356_ CGVGV 361_ SVLDD 366_ LLYAV 371_ GGHDG 376_ SSYLN 381_ SVERY 386_ DPKTN 391_ QWSSD 396_ VAPTS 401_ TCRTS 406_ VGVAV 411_ LGGFL 416_ YAVGG 421_ QDGVS 426_ CLNIV 431_ ERYDP 436_ KENKW 441_ TRVAS 446_ MSTRR 451_ LGVAV 456_ AVLGG 461_ FLYAV 466_ GGSDG 471_ TSPLN 476_ TVERY 481_ NPQEN 486_ RWHTI 491_ APMGT 496_ RRKHL 501_ GCAVY 506_ QDMIY 511_ AVGGR 516_ DDTTE 521_ LSSAE 526_ RYNPR 531_ TNQWS 536_ PVVAM 541_ TSRRS 546_ GVGLA 551_ VVNGQ 556_ LMAVG 561_ GFDGT 566_ TYLKT 571_ IEVFD 576_ PDANT 581_ WRLYG 586_ GMNYR 591_ RLGGG 596_ VGVIK 601_MTHCE
1: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis (PubMed:20389280). The BCR(KLHL20) E3 ubiquitin ligase complex also specifically mediates 'Lys-33'-linked ubiquitination (PubMed:24768539). Involved in anterograde Golgi to endosome transport by mediating 'Lys-33'-linked ubiquitination of CORO7, promoting interaction between CORO7 and EPS15, thereby facilitating actin polymerization and post-Golgi trafficking (PubMed:24768539). Also acts as a regulator of endothelial migration during angiogenesis by controlling the activation of Rho GTPases. The BCR(KLHL20) E3 ubiquitin ligase complex acts as a regulator of neurite outgrowth by mediating ubiquitination and degradation of PDZ-RhoGEF/ARHGEF11 (PubMed:21670212). In case of tumor, the BCR(KLHL20) E3 ubiquitin ligase complex is involved in tumor hypoxia: following hypoxia, the BCR(KLHL20)complex mediates ubiquitination and degradation of PML, potentiating HIF-1 signaling and cancer progression (PubMed:21840486)