Hypoxia-inducible factor 3-alpha (HIF-3-alpha) (HIF3-alpha) (Basic-helix-loop-helix-PAS protein MOP7) (Class E basic helix-loop-helix protein 17) (bHLHe17) (HIF3-alpha-1) (Inhibitory PAS domain protein) (IPAS) (Member of PAS protein 7) (PAS domain-containing protein 7)
1_MALGL 6_ QRARS 11_ TTELR 16_ KEKSR 21_ DAARS 26_ RRSQE 31_ TEVLY 36_ QLAHT 41_ LPFAR 46_ GVSAH 51_ LDKAS 56_ IMRLT 61_ ISYLR 66_ MHRLC 71_ AAGEW 76_ NQVGA 81_ GGEPL 86_ DACYL 91_ KALEG 96_ FVMVL 101_ TAEGD 106_ MAYLS 111_ ENVSK 116_ HLGLS 121_ QLELI 126_ GHSIF 131_ DFIHP 136_ CDQEE 141_ LQDAL 146_ TPQQT 151_ LSRRK 156_ VEAPT 161_ ERCFS 166_ LRMKS 171_ TLTSR 176_ GRTLN 181_ LKAAT 186_ WKVLN 191_ CSGHM 196_ RAYKP 201_ PAQTS 206_ PAGSP 211_ DSEPP 216_ LQCLV 221_ LICEA 226_ IPHPG 231_ SLEPP 236_ LGRGA 241_ FLSRH 246_ SLDMK 251_ FTYCD 256_ DRIAE 261_ VAGYS 266_ PDDLI 271_ GCSAY 276_ EYIHA 281_ LDSDA 286_ VSKSI 291_ HTLLS 296_ KGQAV 301_ TGQYR 306_ FLARS 311_ GGYLW 316_ TQTQA 321_ TVVSG 326_ GRGPQ 331_ SESIV 336_ CVHFL 341_ ISQVE 346_ ETGVV 351_ LSLEQ 356_ TEQHS 361_ RRPIQ 366_ RGAPS 371_ QKDTP 376_ NPGDS 381_ LDTPG 386_ PRILA 391_ FLHPP 396_ SLSEA 401_ ALAAD 406_ PRRFC 411_ SPDLR 416_ RLLGP 421_ ILDGA 426_ SVAAT 431_ PSTPL 436_ ATRHP 441_ QSPLS 446_ ADLPD 451_ ELPVG 456_ TENVH 461_ RLFTS 466_ GKDTE 471_ AVETD 476_ LDIAQ 481_ DADAL 486_ DLEML 491_ APYIS 496_ MDDDF 501_ QLNAS 506_ EQLPR 511_ AYHRP 516_ LGAVP 521_ RPRAR 526_ SFHGL 531_ SPPAL 536_ EPSLL 541_ PRWGS 546_ DPRLS 551_ CSSPS 556_ RGDPS 561_ ASSPM 566_ AGARK 571_ RTLAQ 576_ SSEDE 581_ DEGVE 586_ LLGVR 591_ PPKRS 596_ PSPEH 601_ ENFLL 606_ FPLSL 611_ SFLLT 616_ GGPAP 621_ GSLQD 626_ PSTPL 631_ LNLNE 636_ PLGLG 641_ PSLLS 646_ PYSDE 651_ DTTQP 656_ GGPFQ 661_PRAGS
1: Acts as a transcriptional regulator in adaptive response to low oxygen tension. Acts as a regulator of hypoxia-inducible gene expression (PubMed:11573933, PubMed:16126907, PubMed:19694616, PubMed:20416395, PubMed:21069422). Functions as an inhibitor of angiogenesis in hypoxic cells of the cornea. Plays a role in the development of the cardiorespiratory system. May also be involved in apoptosis (By similarity)
2: Attenuates the ability of transcription factor HIF1A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation. Also inhibits hypoxia-inducible ARNT-mediated gene expression
3: Attenuates the ability of transcription factor HIF1A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation
4: Attenuates the ability of transcription factor HIF1A and EPAS1/HIF2A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation (PubMed:16126907, PubMed:17998805, PubMed:19694616, PubMed:20416395). May act as a tumor suppressor and inhibits malignant cell transformation (PubMed:17998805)
5: Attenuates the ability of transcription factor HIF1A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation