Bile acyl-CoA synthetase (BACS) (EC 6.2.1.7) (Bile acid-CoA ligase) (BA-CoA ligase) (BAL) (Cholate--CoA ligase) (Fatty acid transport protein 5) (FATP-5) (Fatty-acid-coenzyme A ligase, very long-chain 3) (Solute carrier family 27 member 5) (Very long-chain acyl-CoA synthetase homolog 2) (VLCS-H2) (VLCSH2) (Very long-chain acyl-CoA synthetase-related protein) (VLACS-related) (VLACSR)
1_MGVRQ 6_ QLALL 11_ LLLLL 16_ LLWGL 21_ GQPVW 26_ PVAVA 31_ LTLRW 36_ LLGDP 41_ TCCVL 46_ LGLAM 51_ LARPW 56_ LGPWV 61_ PHGLS 66_ LAAAA 71_ LALTL 76_ LPARL 81_ PPGLR 86_ WLPAD 91_ VIFLA 96_ KILHL 101_ GLKIR 106_ GCLSR 111_ QPPDT 116_ FVDAF 121_ ERRAR 126_ AQPGR 131_ ALLVW 136_ TGPGA 141_ GSVTF 146_ GELDA 151_ RACQA 156_ AWALK 161_ AELGD 166_ PASLC 171_ AGEPT 176_ ALLVL 181_ ASQAV 186_ PALCM 191_ WLGLA 196_ KLGCP 201_ TAWIN 206_ PHGRG 211_ MPLAH 216_ SVLSS 221_ GARVL 226_ VVDPD 231_ LRESL 236_ EEILP 241_ KLQAE 246_ NIRCF 251_ YLSHT 256_ SPTPG 261_ VGALG 266_ AALDA 271_ APSHP 276_ VPADL 281_ RAGIT 286_ WRSPA 291_ LFIYT 296_ SGTTG 301_ LPKPA 306_ ILTHE 311_ RVLQM 316_ SKMLS 321_ LSGAT 326_ ADDVV 331_ YTVLP 336_ LYHVM 341_ GLVVG 346_ ILGCL 351_ DLGAT 356_ CVLAP 361_ KFSTS 366_ CFWDD 371_ CRQHG 376_ VTVIL 381_ YVGEL 386_ LRYLC 391_ NIPQQ 396_ PEDRT 401_ HTVRL 406_ AMGNG 411_ LRADV 416_ WETFQ 421_ QRFGP 426_ IRIWE 431_ VYGST 436_ EGNMG 441_ LVNYV 446_ GRCGA 451_ LGKMS 456_ CLLRM 461_ LSPFE 466_ LVQFD 471_ MEAAE 476_ PVRDN 481_ QGFCI 486_ PVGLG 491_ EPGLL 496_ LTKVV 501_ SQQPF 506_ VGYRG 511_ PRELS 516_ ERKLV 521_ RNVRQ 526_ SGDVY 531_ YNTGD 536_ VLAMD 541_ REGFL 546_ YFRDR 551_ LGDTF 556_ RWKGE 561_ NVSTH 566_ EVEGV 571_ LSQVD 576_ FLQQV 581_ NVYGV 586_ CVPGC 591_ EGKVG 596_ MAAVQ 601_ LAPGQ 606_ TFDGE 611_ KLYQH 616_ VRAWL 621_ PAYAT 626_ PHFIR 631_ IQDAM 636_ EVTST 641_ FKLMK 646_ TRLVR 651_ EGFNV 656_ GIVVD 661_ PLFVL 666_ DNRAQ 671_ SFRPL 676_ TAEMY 681_QAVCE
1: May mediate the import of long-chain fatty acids (LCFA) by facilitating their transport across cell membranes (PubMed:20448275, PubMed:20530735). Also catalyzes the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates (PubMed:10479480). Mainly functions as a bile acyl-CoA synthetase catalyzing the activation of bile acids via ATP-dependent formation of bile acid CoA thioesters which is necessary for their subsequent conjugation with glycine or taurine (PubMed:10749848, PubMed:11980911). Both primary bile acids (cholic acid and chenodeoxycholic acid) and secondary bile acids (deoxycholic acid and lithocholic acid) are the principal substrates (PubMed:10749848, PubMed:11980911). In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate ((25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate or THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol (PubMed:11980911). Plays an important role in hepatic fatty acid uptake and bile acid reconjugation and recycling but not in de novo synthesis of bile acids (By similarity)