Phospholipid-transporting ATPase IA (EC 7.6.2.1) (ATPase class I type 8A member 1) (Chromaffin granule ATPase II) (P4-ATPase flippase complex alpha subunit ATP8A1)
1_MPTMR 6_ RTVSE 11_ IRSRA 16_ EGYEK 21_ TDDVS 26_ EKTSL 31_ ADQEE 36_ VRTIF 41_ INQPQ 46_ LTKFC 51_ NNHVS 56_ TAKYN 61_ IITFL 66_ PRFLY 71_ SQFRR 76_ AANSF 81_ FLFIA 86_ LLQQI 91_ PDVSP 96_ TGRYT 101_ TLVPL 106_ LFILA 111_ VAAIK 116_ EIIED 121_ IKRHK 126_ ADNAV 131_ NKKQT 136_ QVLRN 141_ GAWEI 146_ VHWEK 151_ VAVGE 156_ IVKVT 161_ NGEHL 166_ PADLI 171_ SLSSS 176_ EPQAM 181_ CYIET 186_ SNLDG 191_ ETNLK 196_ IRQGL 201_ PATSD 206_ IKDVD 211_ SLMRI 216_ SGRIE 221_ CESPN 226_ RHLYD 231_ FVGNI 236_ RLDGH 241_ GTVPL 246_ GADQI 251_ LLRGA 256_ QLRNT 261_ QWVHG 266_ IVVYT 271_ GHDTK 276_ LMQNS 281_ TSPPL 286_ KLSNV 291_ ERITN 296_ VQILI 301_ LFCIL 306_ IAMSL 311_ VCSVG 316_ SAIWN 321_ RRHSG 326_ KDWYL 331_ NLNYG 336_ GASNF 341_ GLNFL 346_ TFIIL 351_ FNNLI 356_ PISLL 361_ VTLEV 366_ VKFTQ 371_ AYFIN 376_ WDLDM 381_ HYEPT 386_ DTAAM 391_ ARTSN 396_ LNEEL 401_ GQVKY 406_ IFSDK 411_ TGTLT 416_ CNVMQ 421_ FKKCT 426_ IAGVA 431_ YGHVP 436_ EPEDY 441_ GCSPD 446_ EWQNS 451_ QFGDE 456_ KTFSD 461_ SSLLE 466_ NLQNN 471_ HPTAP 476_ IICEF 481_ LTMMA 486_ VCHTA 491_ VPERE 496_ GDKII 501_ YQAAS 506_ PDEGA 511_ LVRAA 516_ KQLNF 521_ VFTGR 526_ TPDSV 531_ IIDSL 536_ GQEER 541_ YELLN 546_ VLEFT 551_ SARKR 556_ MSVIV 561_ RTPSG 566_ KLRLY 571_ CKGAD 576_ TVIYD 581_ RLAET 586_ SKYKE 591_ ITLKH 596_ LEQFA 601_ TEGLR 606_ TLCFA 611_ VAEIS 616_ ESDFQ 621_ EWRAV 626_ YQRAS 631_ TSVQN 636_ RLLKL 641_ EESYE 646_ LIEKN 651_ LQLLG 656_ ATAIE 661_ DKLQD 666_ QVPET 671_ IETLM 676_ KADIK 681_ IWILT 686_ GDKQE 691_ TAINI 696_ GHSCK 701_ LLKKN 706_ MGMIV 711_ INEGS 716_ LDGTR 721_ ETLSR 726_ HCTTL 731_ GDALR 736_ KENDF 741_ ALIID 746_ GKTLK 751_ YALTF 756_ GVRQY 761_ FLDLA 766_ LSCKA 771_ VICCR 776_ VSPLQ 781_ KSEVV 786_ EMVKK 791_ QVKVV 796_ TLAIG 801_ DGAND 806_ VSMIQ 811_ TAHVG 816_ VGISG 821_ NEGLQ 826_ AANSS 831_ DYSIA 836_ QFKYL 841_ KNLLM 846_ IHGAW 851_ NYNRV 856_ SKCIL 861_ YCFYK 866_ NIVLY 871_ IIEIW 876_ FAFVN 881_ GFSGQ 886_ ILFER 891_ WCIGL 896_ YNVMF 901_ TAMPP 906_ LTLGI 911_ FERSC 916_ RKENM 921_ LKYPE 926_ LYKTS 931_ QNALD 936_ FNTKV 941_ FWVHC 946_ LNGLF 951_ HSVIL 956_ FWFPL 961_ KALQY 966_ GTAFG 971_ NGKTS 976_ DYLLL 981_ GNFVY 986_ TFVVI 991_ TVCLK 996_ AGLET 1001_ SYWTW 1006_ FSHIA 1011_ IWGSI 1016_ ALWVV 1021_ FFGIY 1026_ SSLWP 1031_ AIPMA 1036_ PDMSG 1041_ EAAML 1046_ FSSGV 1051_ FWMGL 1056_ LFIPV 1061_ ASLLL 1066_ DVVYK 1071_ VIKRT 1076_ AFKTL 1081_ VDEVQ 1086_ ELEAK 1091_ SQDPG 1096_ AVVLG 1101_ KSLTE 1106_ RAQLL 1111_ KNVFK 1116_ KNHVN 1121_ LYRSE 1126_ SLQQN 1131_ LLHGY 1136_ AFSQD 1141_ ENGIV 1146_ SQSEV 1151_ IRAYD 1156_TTKQR
1: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids (PubMed:31416931). Phospholipid translocation also seems to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS) (PubMed:31416931). The flippase complex ATP8A1:TMEM30A seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the cell membrane (By similarity). Acts as aminophospholipid translocase at the cell membrane in neuronal cells (By similarity)