Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP) (PEST-domain phosphatase) (PEP)
1_MDQRE 6_ ILQKF 11_ LDEAQ 16_ SKKIT 21_ KEEFA 26_ NEFLK 31_ LKRQS 36_ TKYKA 41_ DKTYP 46_ TTVAE 51_ KPKNI 56_ KKNRY 61_ KDILP 66_ YDYSR 71_ VELSL 76_ ITSDE 81_ DSSYI 86_ NANFI 91_ KGVYG 96_ PKAYI 101_ ATQGP 106_ LSTTL 111_ LDFWR 116_ MIWEY 121_ SVLII 126_ VMACM 131_ EYEMG 136_ KKKCE 141_ RYWAE 146_ PGEMQ 151_ LEFGP 156_ FSVSC 161_ EAEKR 166_ KSDYI 171_ IRTLK 176_ VKFNS 181_ ETRTI 186_ YQFHY 191_ KNWPD 196_ HDVPS 201_ SIDPI 206_ LELIW 211_ DVRCY 216_ QEDDS 221_ VPICI 226_ HCSAG 231_ CGRTG 236_ VICAI 241_ DYTWM 246_ LLKDG 251_ IIPEN 256_ FSVFS 261_ LIREM 266_ RTQRP 271_ SLVQT 276_ QEQYE 281_ LVYNA 286_ VLELF 291_ KRQMD 296_ VIRDK 301_ HSGTE 306_ SQAKH 311_ CIPEK 316_ NHTLQ 321_ ADSYS 326_ PNLPK 331_ STTKA 336_ AKMMN 341_ QQRTK 346_ MEIKE 351_ SSSFD 356_ FRTSE 361_ ISAKE 366_ ELVLH 371_ PAKSS 376_ TSFDF 381_ LELNY 386_ SFDKN 391_ ADTTM 396_ KWQTK 401_ AFPIV 406_ GEPLQ 411_ KHQSL 416_ DLGSL 421_ LFEGC 426_ SNSKP 431_ VNAAG 436_ RYFNS 441_ KVPIT 446_ RTKST 451_ PFELI 456_ QQRET 461_ KEVDS 466_ KENFS 471_ YLESQ 476_ PHDSC 481_ FVEMQ 486_ AQKVM 491_ HVSSA 496_ ELNYS 501_ LPYDS 506_ KHQIR 511_ NASNV 516_ KHHDS 521_ SALGV 526_ YSYIP 531_ LVENP 536_ YFSSW 541_ PPSGT 546_ SSKMS 551_ LDLPE 556_ KQDGT 561_ VFPSS 566_ LLPTS 571_ STSLF 576_ SYYNS 581_ HDSLS 586_ LNSPT 591_ NISSL 596_ LNQES 601_ AVLAT 606_ APRID 611_ DEIPP 616_ PLPVR 621_ TPESF 626_ IVVEE 631_ AGEFS 636_ PNVPK 641_ SLSSA 646_ VKVKI 651_ GTSLE 656_ WGGTS 661_ EPKKF 666_ DDSVI 671_ LRPSK 676_ SVKLR 681_ SPKSE 686_ LHQDR 691_ SSPPP 696_ PLPER 701_ TLESF 706_ FLADE 711_ DCMQA 716_ QSIET 721_ YSTSY 726_ PDTME 731_ NSTSS 736_ KQTLK 741_ TPGKS 746_ FTRSK 751_ SLKIL 756_ RNMKK 761_ SICNS 766_ CPPNK 771_ PAESV 776_ QSNNS 781_ SSFLN 786_ FGFAN 791_ RFSKP 796_ KGPRN 801_PPPTW
1: Acts as a negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (PubMed:16461343, PubMed:18056643). Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue (PubMed:21719704). Dephosphorylates ZAP70 at its activating 'Tyr-493' residue (PubMed:16461343). Dephosphorylates the immune system activator SKAP2 (PubMed:21719704). Positively regulates toll-like receptor (TLR)-induced type 1 interferon production (PubMed:23871208). Promotes host antiviral responses mediated by type 1 interferon (By similarity). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy (PubMed:23991106). Acts as an activator of NLRP3 inflammasome assembly by mediating dephosphorylation of 'Tyr-861' of NLRP3 (PubMed:27043286). Dephosphorylates phospho-anandamide (p-AEA), an endocannabinoid to anandamide (also called N-arachidonoylethanolamide) (By similarity)