G-protein coupled receptor 52
1_MNESR 6_ WTEWR 11_ ILNMS 16_ SGIVN 21_ VSERH 26_ SCPLG 31_ FGHYS 36_ VVDVC 41_ IFETV 46_ VIVLL 51_ TFLII 56_ AGNLT 61_ VIFVF 66_ HCAPL 71_ LHHYT 76_ TSYFI 81_ QTMAY 86_ ADLFV 91_ GVSCL 96_ VPTLS 101_ LLHYS 106_ TGVHE 111_ SLTCQ 116_ VFGYI 121_ ISVLK 126_ SVSMA 131_ CLACI 136_ SVDRY 141_ LAITK 146_ PLSYN 151_ QLVTP 156_ CRLRI 161_ CIILI 166_ WIYSC 171_ LIFLP 176_ SFFGW 181_ GKPGY 186_ HGDIF 191_ EWCAT 196_ SWLTS 201_ AYFTG 206_ FIVCL 211_ LYAPA 216_ AFVVC 221_ FTYFH 226_ IFKIC 231_ RQHTK 236_ EINDR 241_ RARFP 246_ SHEVD 251_ SSRET 256_ GHSPD 261_ RRYAM 266_ VLFRI 271_ TSVFY 276_ MLWLP 281_ YIIYF 286_ LLESS 291_ RVLDN 296_ PTLSF 301_ LTTWL 306_ AISNS 311_ FCNCV 316_ IYSLS 321_ NSVFR 326_ LGLRR 331_ LSETM 336_ CTSCM 341_ CVKDQ 346_ EAQEP 351_ KPRKR 356_ANSCS
1: Gs-coupled receptor activated by antipsychotics reserpine leading to an increase in intracellular cAMP and its internalization (PubMed:24587241). May play a role in locomotor activity through modulation of dopamine, NMDA and ADORA2A-induced locomotor activity. These behavioral changes are accompanied by modulation of the dopamine receptor signaling pathway in striatum (PubMed:24587241). Modulates HTT level via cAMP-dependent but PKA independent mechanisms throught activation of RAB39B that translocates HTT to the endoplasmic reticulum, thus avoiding proteasome degradation (PubMed:25738228)