Kelch domain-containing protein 2 (Hepatocellular carcinoma-associated antigen 33) (Host cell factor homolog LCP) (Host cell factor-like protein 1) (HCLP-1)
1_MADGN 6_ EDLRA 11_ DDLPG 16_ PAFES 21_ YESME 26_ LACPA 31_ ERSGH 36_ VAVSD 41_ GRHMF 46_ VWGGY 51_ KSNQV 56_ RGLYD 61_ FYLPR 66_ EELWI 71_ YNMET 76_ GRWKK 81_ INTEG 86_ DVPPS 91_ MSGSC 96_ AVCVD 101_ RVLYL 106_ FGGHH 111_ SRGNT 116_ NKFYM 121_ LDSRS 126_ TDRVL 131_ QWERI 136_ DCQGI 141_ PPSSK 146_ DKLGV 151_ WVYKN 156_ KLIFF 161_ GGYGY 166_ LPEDK 171_ VLGTF 176_ EFDET 181_ SFWNS 186_ SHPRG 191_ WNDHV 196_ HILDT 201_ ETFTW 206_ SQPIT 211_ TGKAP 216_ SPRAA 221_ HACAT 226_ VGNRG 231_ FVFGG 236_ RYRDA 241_ RMNDL 246_ HYLNL 251_ DTWEW 256_ NELIP 261_ QGICP 266_ VGRSW 271_ HSLTP 276_ VSSDH 281_ LFLFG 286_ GFTTD 291_ KQPLS 296_ DAWTY 301_ CISKN 306_ EWIQF 311_ NHPYT 316_ EKPRL 321_ WHTAC 326_ ASDEG 331_ EVIVF 336_ GGCAN 341_ NLLVH 346_ HRAAH 351_ SNEIL 356_ IFSVQ 361_ PKSLV 366_ RLSLE 371_ AVICF 376_ KEMLA 381_ NSWNC 386_ LPKHL 391_ LHSVN 396_ QRFGS 401_NNTSG
1: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29775578, PubMed:29779948, PubMed:30526872, PubMed:36805027, PubMed:38177675). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (PubMed:29775578, PubMed:29779948, PubMed:30526872). The CRL2(KLHDC2) complex specifically recognizes proteins with a diglycine (Gly-Gly) at the C-terminus, leading to their ubiquitination and degradation (PubMed:29775578, PubMed:29779948, PubMed:30526872, PubMed:36805027, PubMed:38177675). The CRL2(KLHDC2) complex mediates ubiquitination and degradation of truncated SELENOK and SELENOS selenoproteins produced by failed UGA/Sec decoding, which end with a diglycine (PubMed:26138980, PubMed:30526872, PubMed:36805027). The CRL2(KLHDC2) complex also recognizes proteolytically cleaved proteins ending with Gly-Gly, such as the N-terminal fragment of USP1, leading to their degradation (PubMed:29775578, PubMed:30526872, PubMed:36805027, PubMed:38177675). May also act as an indirect repressor of CREB3-mediated transcription by interfering with CREB3-DNA-binding (PubMed:11384994)