Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150)
1_MSKTN 6_ KSKSG 11_ SRSSR 16_ SRSAS 21_ RSRSR 26_ SFSKS 31_ RSRSR 36_ SLSRS 41_ RKRRL 46_ SSRSR 51_ SRSYS 56_ PAHNR 61_ ERNHP 66_ RVYQN 71_ RDFRG 76_ HNRGY 81_ RRPYY 86_ FRGRN 91_ RGFYP 96_ WGQYN 101_ RGGYG 106_ NYRSN 111_ WQNYR 116_ QAYSP 121_ RRGRS 126_ RSRSP 131_ KRRSP 136_ SPRSR 141_ SHSRN 146_ SDKSS 151_ SDRSR 156_ RSSSS 161_ RSSSN 166_ HSRVE 171_ SSKRK 176_ SAKEK 181_ KSSSK 186_ DSRPS 191_ QAAGD 196_ NQGDE 201_ AKEQT 206_ FSGGT 211_ SQDTK 216_ ASESS 221_ KPWPD 226_ ATYGT 231_ GSASR 236_ ASAVS 241_ ELSPR 246_ ERSPA 251_ LKSPL 256_ QSVVV 261_ RRRSP 266_ RPSPV 271_ PKPSP 276_ PLSST 281_ SQMGS 286_ TLPSG 291_ AGYQS 296_ GTHQG 301_ QFDHG 306_ SGSLS 311_ PSKKS 316_ PVGKS 321_ PPSTG 326_ STYGS 331_ SQKEE 336_ SAASG 341_ GAAYT 346_ KRYLE 351_ EQKTE 356_ NGKDK 361_ EQKQT 366_ NTDKE 371_ KIKEK 376_ GSFSD 381_ TGLGD 386_ GKMKS 391_ DSFAP 396_ KTDSE 401_ KPFRG 406_ SQSPK 411_ RYKLR 416_ DDFEK 421_ KMADF 426_ HKEEM 431_ DDQDK 436_ DKAKG 441_ RKESE 446_ FDDEP 451_ KFMSK 456_ VIGAN 461_ KNQEE 466_ EKSGK 471_ WEGLV 476_ YAPPG 481_ KEKQR 486_ KTEEL 491_ EEESF 496_ PERSK 501_ KEDRG 506_ KRSEG 511_ GHRGF 516_ VPEKN 521_ FRVTA 526_ YKAVQ 531_ EKSSS 536_ PPPRK 541_ TSESR 546_ DKLGA 551_ KGDFP 556_ TGKSS 561_ FSITR 566_ EAQVN 571_ VRMDS 576_ FDEDL 581_ ARPSG 586_ LLAQE 591_ RKLCR 596_ DLVHS 601_ NKKEQ 606_ EFRSI 611_ FQHIQ 616_ SAQSQ 621_ RSPSE 626_ LFAQH 631_ IVTIV 636_ HHVKE 641_ HHFGS 646_ SGMTL 651_ HERFT 656_ KYLKR 661_ GTEQE 666_ AAKNK 671_ KSPEI 676_ HRRID 681_ ISPST 686_ FRKHG 691_ LAHDE 696_ MKSPR 701_ EPGYK 706_ AEGKY 711_ KDDPV 716_ DLRLD 721_ IERRK 726_ KHKER 731_ DLKRG 736_ KSRES 741_ VDSRD 746_ SSHSR 751_ ERSAE 756_ KTEKT 761_ HKGSK 766_ KQKKH 771_ RRARD 776_ RSRSS 781_ SSSSQ 786_ SSHSY 791_ KAEEY 796_ TEETE 801_ EREES 806_ TTGFD 811_ KSRLG 816_ TKDFV 821_ GPSER 826_ GGGRA 831_ RGTFQ 836_ FRARG 841_ RGWGR 846_ GNYSG 851_ NNNNN 856_ SNNDF 861_ QKRNR 866_ EEEWD 871_ PEYTP 876_ KSKKY 881_ YLHDD 886_ REGEG 891_ SDKWV 896_ SRGRG 901_ RGAFP 906_ RGRGR 911_ FMFRK 916_ SSTSP 921_ KWAHD 926_ KFSGE 931_ EGEIE 936_ DDESG 941_ TENRE 946_EKDNI
1: Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798)