Calsenilin (A-type potassium channel modulatory protein 3) (DRE-antagonist modulator) (DREAM) (Kv channel-interacting protein 3) (KChIP3)
1_MQPAK 6_ EVTKA 11_ SDGSL 16_ LGDLG 21_ HTPLS 26_ KKEGI 31_ KWQRP 36_ RLSRQ 41_ ALMRC 46_ CLVKW 51_ ILSST 56_ APQGS 61_ DSSDS 66_ ELELS 71_ TVRHQ 76_ PEGLD 81_ QLQAQ 86_ TKFTK 91_ KELQS 96_ LYRGF 101_ KNECP 106_ TGLVD 111_ EDTFK 116_ LIYAQ 121_ FFPQG 126_ DATTY 131_ AHFLF 136_ NAFDA 141_ DGNGA 146_ IHFED 151_ FVVGL 156_ SILLR 161_ GTVHE 166_ KLKWA 171_ FNLYD 176_ INKDG 181_ YITKE 186_ EMLAI 191_ MKSIY 196_ DMMGR 201_ HTYPI 206_ LREDA 211_ PAEHV 216_ ERFFE 221_ KMDRN 226_ QDGVV 231_ TIEEF 236_ LEACQ 241_ KDENI 246_ MSSMQ 251_LFENV
1: Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception (By similarity)
2: Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner
3: May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of amyloid-beta formation