Nucleolar protein 58 (Nucleolar protein 5)
1_MLVLF 6_ ETSVG 11_ YAIFK 16_ VLNEK 21_ KLQEV 26_ DSLWK 31_ EFETP 36_ EKANK 41_ IVKLK 46_ HFEKF 51_ QDTAE 56_ ALAAF 61_ TALME 66_ GKINK 71_ QLKKV 76_ LKKIV 81_ KEAHE 86_ PLAVA 91_ DAKLG 96_ GVIKE 101_ KLNLS 106_ CIHSP 111_ VVNEL 116_ MRGIR 121_ SQMDG 126_ LIPGV 131_ EPREM 136_ AAMCL 141_ GLAHS 146_ LSRYR 151_ LKFSA 156_ DKVDT 161_ MIVQA 166_ ISLLD 171_ DLDKE 176_ LNNYI 181_ MRCRE 186_ WYGWH 191_ FPELG 196_ KIISD 201_ NLTYC 206_ KCLQK 211_ VGDRK 216_ NYASA 221_ KLSEL 226_ LPEEV 231_ EAEVK 236_ AAAEI 241_ SMGTE 246_ VSEED 251_ ICNIL 256_ HLCTQ 261_ VIEIS 266_ EYRTQ 271_ LYEYL 276_ QNRMM 281_ AIAPN 286_ VTVMV 291_ GELVG 296_ ARLIA 301_ HAGSL 306_ LNLAK 311_ HAAST 316_ VQILG 321_ AEKAL 326_ FRALK 331_ SRRDT 336_ PKYGL 341_ IYHAS 346_ LVGQT 351_ SPKHK 356_ GKISR 361_ MLAAK 366_ TVLAI 371_ RYDAF 376_ GEDSS 381_ SAMGV 386_ ENRAK 391_ LEARL 396_ RTLED 401_ RGIRK 406_ ISGTG 411_ KALAK 416_ TEKYE 421_ HKSEV 426_ KTYDP 431_ SGDST 436_ LPTCS 441_ KKRKI 446_ EQVDK 451_ EDEIT 456_ EKKAK 461_ KAKIK 466_ VKVEE 471_ EEEEK 476_ VAEEE 481_ ETSVK 486_ KKKKR 491_ GKKKH 496_ IKEEP 501_ LSEEE 506_ PCTST 511_ AIASP 516_ EKKKK 521_KKKKR
1: Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs (PubMed:15574333, PubMed:17636026, PubMed:19620283, PubMed:34516797). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs) (PubMed:39570315)