Nitric oxide synthase-interacting protein (E3 ubiquitin-protein ligase NOSIP) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase NOSIP) (eNOS-interacting protein)
1_MTRHG 6_ KNCTA 11_ GAVYT 16_ YHEKK 21_ KDTAA 26_ SGYGT 31_ QNIRL 36_ SRDAV 41_ KDFDC 46_ CCLSL 51_ QPCHD 56_ PVVTP 61_ DGYLY 66_ EREAI 71_ LEYIL 76_ HQKKE 81_ IARQM 86_ KAYEK 91_ QRGTR 96_ REEQK 101_ ELQRA 106_ ASQDH 111_ VRGFL 116_ EKESA 121_ IVSRP 126_ LNPFT 131_ AKALS 136_ GTSPD 141_ DVQPG 146_ PSVGP 151_ PSKDK 156_ DKVLP 161_ SFWIP 166_ SLTPE 171_ AKATK 176_ LEKPS 181_ RTVTC 186_ PMSGK 191_ PLRMS 196_ DLTPV 201_ HFTPL 206_ DSSVD 211_ RVGLI 216_ TRSER 221_ YVCAV 226_ TRDSL 231_ SNATP 236_ CAVLR 241_ PSGAV 246_ VTLEC 251_ VEKLI 256_ RKDMV 261_ DPVTG 266_ DKLTD 271_ RDIIV 276_ LQRGG 281_ TGFAG 286_ SGVKL 291_ QAEKS 296_RPVMQ
1: E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity (PubMed:11149895, PubMed:15548660, PubMed:16135813)