Protein MEMO1 (C21orf19-like protein) (Hepatitis C virus NS5A-transactivated protein 7) (HCV NS5A-transactivated protein 7) (Mediator of ErbB2-driven cell motility 1) (Mediator of cell motility 1) (Memo-1)
1_MSNRV 6_ VCREA 11_ SHAGS 16_ WYTAS 21_ GPQLN 26_ AQLEG 31_ WLSQV 36_ QSTKR 41_ PARAI 46_ IAPHA 51_ GYTYC 56_ GSCAA 61_ HAYKQ 66_ VDPSI 71_ TRRIF 76_ ILGPS 81_ HHVPL 86_ SRCAL 91_ SSVDI 96_ YRTPL 101_ YDLRI 106_ DQKIY 111_ GELWK 116_ TGMFE 121_ RMSLQ 126_ TDEDE 131_ HSIEM 136_ HLPYT 141_ AKAME 146_ SHKDE 151_ FTIIP 156_ VLVGA 161_ LSESK 166_ EQEFG 171_ KLFSK 176_ YLADP 181_ SNLFV 186_ VSSDF 191_ CHWGQ 196_ RFRYS 201_ YYDES 206_ QGEIY 211_ RSIEH 216_ LDKMG 221_ MSIIE 226_ QLDPV 231_ SFSNY 236_ LKKYH 241_ NTICG 246_ RHPIG 251_ VLLNA 256_ ITELQ 261_ KNGMN 266_ MSFSF 271_ LNYAQ 276_ SSQCR 281_ NWQDS 286_ SVSYA 291_AGALT
1: May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration