Endophilin-B1 (Bax-interacting factor 1) (Bif-1) (SH3 domain-containing GRB2-like protein B1)
1_MNIMD 6_ FNVKK 11_ LAADA 16_ GTFLS 21_ RAVQF 26_ TEEKL 31_ GQAEK 36_ TELDA 41_ HLENL 46_ LSKAE 51_ CTKIW 56_ TEKIM 61_ KQTEV 66_ LLQPN 71_ PNARI 76_ EEFVY 81_ EKLDR 86_ KAPSR 91_ INNPE 96_ LLGQY 101_ MIDAG 106_ TEFGP 111_ GTAYG 116_ NALIK 121_ CGETQ 126_ KRIGT 131_ ADREL 136_ IQTSA 141_ LNFLT 146_ PLRNF 151_ IEGDY 156_ KTIAK 161_ ERKLL 166_ QNKRL 171_ DLDAA 176_ KTRLK 181_ KAKAA 186_ ETRNS 191_ SEQEL 196_ RITQS 201_ EFDRQ 206_ AEITR 211_ LLLEG 216_ ISSTH 221_ AHHLR 226_ CLNDF 231_ VEAQM 236_ TYYAQ 241_ CYQYM 246_ LDLQK 251_ QLGSF 256_ PSNYL 261_ SNNNQ 266_ TSVTP 271_ VPSVL 276_ PNAIG 281_ SSAMA 286_ STSGL 291_ VITSP 296_ SNLSD 301_ LKECS 306_ GSRKA 311_ RVLYD 316_ YDAAN 321_ STELS 326_ LLADE 331_ VITVF 336_ SVVGM 341_ DSDWL 346_ MGERG 351_ NQKGK 356_VPITY
1: May be required for normal outer mitochondrial membrane dynamics (PubMed:15452144). Required for coatomer-mediated retrograde transport in certain cells (By similarity). May recruit other proteins to membranes with high curvature. May promote membrane fusion (PubMed:11604418). Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation (PubMed:16227588). Isoform 1 acts proapoptotic in fibroblasts (By similarity). Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2) (PubMed:17891140). Associated with PI3KC3-C2 during autophagy may regulate the trafficking of ATG9A from the Golgi complex to the peripheral cytoplasm for the formation of autophagosomes by inducing Golgi membrane tubulation and fragmentation (PubMed:21068542). Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123). Isoform 2 acts antiapoptotic in neuronal cells; involved in maintenance of mitochondrial morphology and promotes neuronal viability (By similarity)