Ubiquitin-conjugating enzyme E2 J1 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme J1) (Non-canonical ubiquitin-conjugating enzyme 1) (NCUBE-1) (Yeast ubiquitin-conjugating enzyme UBC6 homolog E) (HsUBC6e)
1_METRY 6_ NLKSP 11_ AVKRL 16_ MKEAA 21_ ELKDP 26_ TDHYH 31_ AQPLE 36_ DNLFE 41_ WHFTV 46_ RGPPD 51_ SDFDG 56_ GVYHG 61_ RIVLP 66_ PEYPM 71_ KPPSI 76_ ILLTA 81_ NGRFE 86_ VGKKI 91_ CLSIS 96_ GHHPE 101_ TWQPS 106_ WSIRT 111_ ALLAI 116_ IGFMP 121_ TKGEG 126_ AIGSL 131_ DYTPE 136_ ERRAL 141_ AKKSQ 146_ DFCCE 151_ GCGSA 156_ MKDVL 161_ LPLKS 166_ GSDSS 171_ QADQE 176_ AKELA 181_ RQISF 186_ KAEVN 191_ SSGKT 196_ ISESD 201_ LNHSF 206_ SLTDL 211_ QDDIP 216_ TTFQG 221_ ATAST 226_ SYGLQ 231_ NSSAA 236_ SFHQP 241_ TQPVA 246_ KNTSM 251_ SPRQR 256_ RAQQQ 261_ SQRRL 266_ STSPD 271_ VIQGH 276_ QPRDN 281_ HTDHG 286_ GSAVL 291_ IVILT 296_ LALAA 301_ LIFRR 306_ IYLAN 311_EYIFD
1: Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD) and is essential for cells to recover from ER stress (PubMed:28321712). Plays a role in MAPKAPK2-dependent translational control of TNF-alpha synthesis (PubMed:24020373). Also acts as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1 through interaction with the E3 ubiquitin-protein ligase RNF26 (PubMed:33472082). Plays a role in male fecundity through the interaction with the E3 ubiquitin-protein ligase RNF133 (PubMed:35831855)
2: (Microbial infection) Promotes Dengue virus RNA replication by negatively regulating IFN-beta signaling and mediating 'Lys-48'-linked ubiquitination on IRF3 (PubMed:30157886)