Dehydrogenase/reductase SDR family member 7 (EC 1.1.1.-) (Retinal short-chain dehydrogenase/reductase 4) (retSDR4) (Short chain dehydrogenase/reductase family 34C member 1) (Protein SDR34C1)
1_MNWEL 6_ LLWLL 11_ VLCAL 16_ LLLLV 21_ QLLRF 26_ LRADG 31_ DLTLL 36_ WAEWQ 41_ GRRPE 46_ WELTD 51_ MVVWV 56_ TGASS 61_ GIGEE 66_ LAYQL 71_ SKLGV 76_ SLVLS 81_ ARRVH 86_ ELERV 91_ KRRCL 96_ ENGNL 101_ KEKDI 106_ LVLPL 111_ DLTDT 116_ GSHEA 121_ ATKAV 126_ LQEFG 131_ RIDIL 136_ VNNGG 141_ MSQRS 146_ LCMDT 151_ SLDVY 156_ RKLIE 161_ LNYLG 166_ TVSLT 171_ KCVLP 176_ HMIER 181_ KQGKI 186_ VTVNS 191_ ILGII 196_ SVPLS 201_ IGYCA 206_ SKHAL 211_ RGFFN 216_ GLRTE 221_ LATYP 226_ GIIVS 231_ NICPG 236_ PVQSN 241_ IVENS 246_ LAGEV 251_ TKTIG 256_ NNGDQ 261_ SHKMT 266_ TSRCV 271_ RLMLI 276_ SMAND 281_ LKEVW 286_ ISEQP 291_ FLLVT 296_ YLWQY 301_ MPTWA 306_ WWITN 311_ KMGKK 316_ RIENF 321_ KSGVD 326_ ADSSY 331_FKIFK
1: NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including steroids, retinoids and xenobiotics (PubMed:24246760, PubMed:26466768, PubMed:28457967, PubMed:28687384). Catalyzes the reduction/inactivation of 5alpha-dihydrotestosterone to 3alpha-androstanediol, with a possible role in the modulation of androgen receptor function (PubMed:28457967, PubMed:28687384). Involved in the reduction of all-trans-retinal to all-trans-retinol (PubMed:26466768). Converts cortisone to 20beta-dihydrocortisone in vitro, although the physiological relevance of this activity is questionable (PubMed:28457967). Reduces exogenous compounds such as quinones (1,2-naphtoquinone, 9,10-phenantrenequinone and benzoquinone) and other xenobiotics (alpha-diketones) in vitro, suggesting a role in the biotransformation of xenobiotics with carbonyl group (PubMed:24246760, PubMed:26466768). A dehydrogenase activity has not been detected so far (PubMed:24246760). May play a role as tumor suppressor (PubMed:26311046)