Ribosomal RNA-processing protein 7 homolog A (Gastric cancer antigen Zg14)
1_MVARR 6_ RKCAA 11_ RDPED 16_ RIPSP 21_ LGYAA 26_ IPIKF 31_ SEKQQ 36_ ASHYL 41_ YVRAH 46_ GVRQG 51_ TKSTW 56_ PQKRT 61_ LFVLN 66_ VPPYC 71_ TEESL 76_ SRLLS 81_ TCGLV 86_ QSVEL 91_ QEKPD 96_ LAESP 101_ KESRS 106_ KFFHP 111_ KPVPG 116_ FQVAY 121_ VVFQK 126_ PSGVS 131_ AALAL 136_ KGPLL 141_ VSTES 146_ HPVKS 151_ GIHKW 156_ ISDYA 161_ DSVPD 166_ PEALR 171_ VEVDT 176_ FMEAY 181_ DQKIA 186_ EEEAK 191_ AKEEE 196_ GVPDE 201_ EGWVK 206_ VTRRG 211_ RRPVL 216_ PRTEA 221_ ASLRV 226_ LERER 231_ RKRSR 236_ KELLN 241_ FYAWQ 246_ HRESK 251_ MEHLA 256_ QLRKK 261_ FEEDK 266_ QRIEL 271_LRAQR
1: Nucleolar protein that is involved in ribosomal RNA (rRNA) processing (PubMed:33199730). Also plays a role in primary cilia resorption, and cell cycle progression in neurogenesis and neocortex development (PubMed:33199730). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797)