Ribosome maturation protein SBDS (Shwachman-Bodian-Diamond syndrome protein)
1_MSIFT 6_ PTNQI 11_ RLTNV 16_ AVVRM 21_ KRAGK 26_ RFEIA 31_ CYKNK 36_ VVGWR 41_ SGVEK 46_ DLDEV 51_ LQTHS 56_ VFVNV 61_ SKGQV 66_ AKKED 71_ LISAF 76_ GTDDQ 81_ TEICK 86_ QILTK 91_ GEVQV 96_ SDKER 101_ HTQLE 106_ QMFRD 111_ IATIV 116_ ADKCV 121_ NPETK 126_ RPYTV 131_ ILIER 136_ AMKDI 141_ HYSVK 146_ TNKST 151_ KQQAL 156_ EVIKQ 161_ LKEKM 166_ KIERA 171_ HMRLR 176_ FILPV 181_ NEGKK 186_ LKEKL 191_ KPLIK 196_ VIESE 201_ DYGQQ 206_ LEIVC 211_ LIDPG 216_ CFREI 221_ DELIK 226_ KETKG 231_ KGSLE 236_ VLNLK 241_DVEEG
1: Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation