ER membrane protein complex subunit 9 (Protein FAM158A)
1_MGEVE 6_ ISALA 11_ YVKMC 16_ LHAAR 21_ YPHAA 26_ VNGLF 31_ LAPAP 36_ RSGEC 41_ LCLTD 46_ CVPLF 51_ HSHLA 56_ LSVML 61_ EVALN 66_ QVDVW 71_ GAQAG 76_ LVVAG 81_ YYHAN 86_ AAVND 91_ QSPGP 96_ LALKI 101_ AGRIA 106_ EFFPD 111_ AVLIM 116_ LDNQK 121_ LVPQP 126_ RVPPV 131_ IVLEN 136_ QGLRW 141_ VPKDK 146_ NLVMW 151_ RDWEE 156_ SRQMV 161_ GALLE 166_ DRAHQ 171_ HLVDF 176_ DCHLD 181_ DIRQD 186_ WTNQR 191_ LNTQI 196_ TQWVG 201_PTNGN
1: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:29242231, PubMed:29809151, PubMed:30415835, PubMed:32459176). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:29242231, PubMed:29809151, PubMed:30415835). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:29809151, PubMed:30415835). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29242231, PubMed:29809151). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable)