Oligoribonuclease, mitochondrial (EC 3.1.15.-) (RNA exonuclease 2 homolog) (Small fragment nuclease)
1_MLGGS 6_ LGSRL 11_ LRGVG 16_ GSHGR 21_ FGARG 26_ VREGG 31_ AAMAA 36_ GESMA 41_ QRMVW 46_ VDLEM 51_ TGLDI 56_ EKDQI 61_ IEMAC 66_ LITDS 71_ DLNIL 76_ AEGPN 81_ LIIKQ 86_ PDELL 91_ DSMSD 96_ WCKEH 101_ HGKSG 106_ LTKAV 111_ KESTI 116_ TLQQA 121_ EYEFL 126_ SFVRQ 131_ QTPPG 136_ LCPLA 141_ GNSVH 146_ EDKKF 151_ LDKYM 156_ PQFMK 161_ HLHYR 166_ IIDVS 171_ TVKEL 176_ CRRWY 181_ PEEYE 186_ FAPKK 191_ AASHR 196_ ALDDI 201_ SESIK 206_ ELQFY 211_ RNNIF 216_ KKKID 221_ EKKRK 226_ IIENG 231_ENEKT
1: 3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides (PubMed:23741365, PubMed:30926754, PubMed:31588022, PubMed:32365187). Binds and degrades longer oligonucleotides with a lower affinity (PubMed:30926754, PubMed:31588022, PubMed:32365187). Plays dual roles in mitochondria, scavenging nanoRNAs (small RNA oligonucleotides of <5 nucleotides) that are produced by the degradosome and clearing short RNAs that are generated by RNA processing (PubMed:30926754, PubMed:31588022, PubMed:32365187). Essential for correct initiation of mitochondrial transcription, degrading mitochondrial RNA dinucleotides to prevent RNA-primed transcription at non-canonical sites in the mitochondrial genome (PubMed:31588022). Essential for embryonic development (By similarity)
2: 3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides