WASH complex subunit 3 (Coiled-coil domain-containing protein 53)
1_MDEDG 6_ LPLMG 11_ SGIDL 16_ TKVPA 21_ IQQKR 26_ TVAFL 31_ NQFVV 36_ HTVQF 41_ LNRFS 46_ TVCEE 51_ KLADL 56_ SLRIQ 61_ QIETT 66_ LNILD 71_ AKLSS 76_ IPGLD 81_ DVTVE 86_ VSPLN 91_ VTSVT 96_ NGAHP 101_ EATSE 106_ QPQQN 111_ STQDS 116_ GLQES 121_ EVSAE 126_ NILTV 131_ AKDPR 136_ YARYL 141_ KMVQV 146_ GVPVM 151_ AIRNK 156_ MISEG 161_ LDPDL 166_ LERPD 171_ APVPD 176_ GESEK 181_ TVEES 186_SDSES
1: Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting