EKC/KEOPS complex subunit TPRKB (PRPK-binding protein) (TP53RK-binding protein)
1_MQLTH 6_ QLDLF 11_ PECRV 16_ TLLLF 21_ KDVKN 26_ AGDLR 31_ RKAME 36_ GTIDG 41_ SLINP 46_ TVIVD 51_ PFQIL 56_ VAANK 61_ AVHLY 66_ KLGKM 71_ KTRTL 76_ STEII 81_ FNLSP 86_ NNNIS 91_ EALKK 96_ FGISA 101_ NDTSI 106_ LIVYI 111_ EEGEK 116_ QINQE 121_ YLISQ 126_ VEGHQ 131_ VSLKN 136_ LPEIM 141_ NITEV 146_ KKIYK 151_ LSSQE 156_ ESIGT 161_ LLDAI 166_ICRMS
1: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:28805828). The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:28805828). TPRKB acts as an allosteric effector that regulates the t(6)A activity of the complex. TPRKB is not required for tRNA modification (PubMed:22912744, PubMed:28805828)