RING finger protein 11
1_MGNCL 6_ KSPTS 11_ DDISL 16_ LHESQ 21_ SDRAS 26_ FGEGT 31_ EPDQE 36_ PPPPY 41_ QEQVP 46_ VPVYH 51_ PTPSQ 56_ TRLAT 61_ QLTEE 66_ EQIRI 71_ AQRIG 76_ LIQHL 81_ PKGVY 86_ DPGRD 91_ GSEKK 96_ IRECV 101_ ICMMD 106_ FVYGD 111_ PIRFL 116_ PCMHI 121_ YHLDC 126_ IDDWL 131_ MRSFT 136_ CPSCM 141_ EPVDA 146_ALLSS
1: Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome