Peptidyl-prolyl cis-trans isomerase-like 1 (PPIase) (EC 5.2.1.8) (Rotamase PPIL1)
1_MAAIP 6_ PDSWQ 11_ PPNVY 16_ LETSM 21_ GIIVL 26_ ELYWK 31_ HAPKT 36_ CKNFA 41_ ELARR 46_ GYYNG 51_ TKFHR 56_ IIKDF 61_ MIQGG 66_ DPTGT 71_ GRGGA 76_ SIYGK 81_ QFEDE 86_ LHPDL 91_ KFTGA 96_ GILAM 101_ ANAGP 106_ DTNGS 111_ QFFVT 116_ LAPTQ 121_ WLDGK 126_ HTIFG 131_ RVCQG 136_ IGMVN 141_ RVGMV 146_ ETNSQ 151_ DRPVD 156_ DVKII 161_KAYPS
1: Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770, PubMed:33220177). PPIases accelerate the folding of proteins. Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (PubMed:16595688). Catalyzes prolyl peptide bond isomerization in CDC40/PRP17 (PubMed:33220177). Plays an important role in embryonic brain development; this function is independent of its isomerase activity (PubMed:33220177)