Ubiquitin-fold modifier-conjugating enzyme 1 (Ufm1-conjugating enzyme 1)
1_MADEA 6_ TRRVV 11_ SEIPV 16_ LKTNA 21_ GPRDR 26_ ELWVQ 31_ RLKEE 36_ YQSLI 41_ RYVEN 46_ NKNAD 51_ NDWFR 56_ LESNK 61_ EGTRW 66_ FGKCW 71_ YIHDL 76_ LKYEF 81_ DIEFD 86_ IPITY 91_ PTTAP 96_ EIAVP 101_ ELDGK 106_ TAKMY 111_ RGGKI 116_ CLTDH 121_ FKPLW 126_ ARNVP 131_ KFGLA 136_ HLMAL 141_ GLGPW 146_ LAVEI 151_ PDLIQ 156_ KGVIQ 161_HKEKC
1: E2-like enzyme which specifically catalyzes the second step in ufmylation (PubMed:15071506, PubMed:29868776, PubMed:30626644, PubMed:34588452, PubMed:35394863, PubMed:36121123, PubMed:38383789). Accepts the ubiquitin-like modifier UFM1 from the E1 enzyme UBA5 and forms an intermediate with UFM1 via a thioester linkage (PubMed:15071506, PubMed:29868776, PubMed:34588452, PubMed:38383789). Ufmylation is involved in various processes, such as ribosome recycling, response to DNA damage, interferon response or reticulophagy (also called ER-phagy) (PubMed:27351204, PubMed:32160526, PubMed:35394863, PubMed:37036982, PubMed:38383789)