Cytosolic iron-sulfur assembly component 2B (MSS19-interacting protein of 18 kDa) (Mitotic spindle-associated MMXD complex subunit MIP18) (Protein FAM96B)
1_MVGGG 6_ GVGGG 11_ LLENA 16_ NPLIY 21_ QRSGE 26_ RPVTA 31_ GEEDE 36_ QVPDS 41_ IDARE 46_ IFDLI 51_ RSIND 56_ PEHPL 61_ TLEEL 66_ NVVEQ 71_ VRVQV 76_ SDPES 81_ TVAVA 86_ FTPTI 91_ PHCSM 96_ ATLIG 101_ LSIKV 106_ KLLRS 111_ LPQRF 116_ KMDVH 121_ ITPGT 126_ HASEH 131_ AVNKQ 136_ LADKE 141_ RVAAA 146_ LENTH 151_ LLEVV 156_NQCLS
1: Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (PubMed:22678361, PubMed:22678362, PubMed:23891004, PubMed:29848660). As a CIA complex component and in collaboration with CIAO1 and MMS19, binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins (PubMed:23891004, PubMed:29848660). As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD (PubMed:20797633). Together with MMS19, facilitates the transfer of Fe-S clusters to the motor protein KIF4A, which ensures proper localization of KIF4A to mitotic machinery components to promote the progression of mitosis (PubMed:29848660)