Methionine-R-sulfoxide reductase B2, mitochondrial (MsrB2) (EC 1.8.4.12) (EC 1.8.4.14)
1_MARLL 6_ WLLRG 11_ LTLGT 16_ APRRA 21_ VRGQA 26_ GGGGP 31_ GTGPG 36_ LGEAG 41_ SLATC 46_ ELPLA 51_ KSEWQ 56_ KKLTP 61_ EQFYV 66_ TREKG 71_ TEPPF 76_ SGIYL 81_ NNKEA 86_ GMYHC 91_ VCCDS 96_ PLFSS 101_ EKKYC 106_ SGTGW 111_ PSFSE 116_ AHGTS 121_ GSDES 126_ HTGIL 131_ RRLDT 136_ SLGSA 141_ RTEVV 146_ CKQCE 151_ AHLGH 156_ VFPDG 161_ PGPNG 166_ QRFCI 171_ NSVAL 176_KFKPR
1: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance