Mitochondrial fission 1 protein (FIS1 homolog) (hFis1) (Tetratricopeptide repeat protein 11) (TPR repeat protein 11)
1_MEAVL 6_ NELVS 11_ VEDLL 16_ KFEKK 21_ FQSEK 26_ AAGSV 31_ SKSTQ 36_ FEYAW 41_ CLVRS 46_ KYNDD 51_ IRKGI 56_ VLLEE 61_ LLPKG 66_ SKEEQ 71_ RDYVF 76_ YLAVG 81_ NYRLK 86_ EYEKA 91_ LKYVR 96_ GLLQT 101_ EPQNN 106_ QAKEL 111_ ERLID 116_ KAMKK 121_ DGLVG 126_ MAIVG 131_ GMALG 136_ VAGLA 141_ GLIGL 146_AVSKS
1: Involved in the fragmentation of the mitochondrial network and its perinuclear clustering (PubMed:12783892, PubMed:12861026, PubMed:14996942, PubMed:23283981). Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission (PubMed:12861026, PubMed:16118244, PubMed:23283981, PubMed:23530241, PubMed:24196833). May not be essential for the assembly of functional fission complexes and the subsequent membrane scission event (PubMed:23530241, PubMed:24196833). Also mediates peroxisomal fission (PubMed:16107562). May act when the products of fission are directed toward mitochondrial homeostasis, mitophagy, or apoptosis (PubMed:24196833). Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis (PubMed:12783892)