Adenylate kinase isoenzyme 6 (AK6) (EC 2.7.4.3) (Adrenal gland protein AD-004) (Coilin-interacting nuclear ATPase protein) (hCINAP) (Dual activity adenylate kinase/ATPase) (AK/ATPase)
1_MLLPN 6_ ILLTG 11_ TPGVG 16_ KTTLG 21_ KELAS 26_ KSGLK 31_ YINVG 36_ DLARE 41_ EQLYD 46_ GYDEE 51_ YDCPI 56_ LDEDR 61_ VVDEL 66_ DNQMR 71_ EGGVI 76_ VDYHG 81_ CDFFP 86_ ERWFH 91_ IVFVL 96_ RTDTN 101_ VLYER 106_ LETRG 111_ YNEKK 116_ LTDNI 121_ QCEIF 126_ QVLYE 131_ EATAS 136_ YKEEI 141_ VHQLP 146_ SNKPE 151_ ELENN 156_ VDQIL 161_ KWIEQ 166_WIKDH
1: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Also has ATPase activity (PubMed:15630091). Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation (PubMed:27477389). While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit (By similarity). Its NMP activity may have a role in nuclear energy homeostasis. AMP and dAMP are the preferred substrates, but CMP and dCMP are also good substrates. IMP is phosphorylated to a much lesser extent. All nucleoside triphosphates ATP, GTP, UTP, CTP, dATP, dCTP, dGTP, and TTP are accepted as phosphate donors. CTP is the best phosphate donor, followed by UTP, ATP, GTP and dCTP. May be involved in regulation of Cajal body (CB) formation (PubMed:15630091)