Charged multivesicular body protein 3 (Chromatin-modifying protein 3) (Neuroendocrine differentiation factor) (Vacuolar protein sorting-associated protein 24) (hVps24)
1_MGLFG 6_ KTQEK 11_ PPKEL 16_ VNEWS 21_ LKIRK 26_ EMRVV 31_ DRQIR 36_ DIQRE 41_ EEKVK 46_ RSVKD 51_ AAKKG 56_ QKDVC 61_ IVLAK 66_ EMIRS 71_ RKAVS 76_ KLYAS 81_ KAHMN 86_ SVLMG 91_ MKNQL 96_ AVLRV 101_ AGSLQ 106_ KSTEV 111_ MKAMQ 116_ SLVKI 121_ PEIQA 126_ TMREL 131_ SKEMM 136_ KAGII 141_ EEMLE 146_ DTFES 151_ MDDQE 156_ EMEEE 161_ AEMEI 166_ DRILF 171_ EITAG 176_ ALGKA 181_ PSKVT 186_ DALPE 191_ PEPPG 196_ AMAAS 201_ EDEEE 206_ EEEAL 211_ EAMQS 216_RLATL
1: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Selectively binds to phosphatidylinositol 3,5-bisphosphate PtdIns(3,5)P2 and PtdIns(3,4)P2 in preference to other phosphoinositides tested. Involved in late stages of cytokinesis. Plays a role in endosomal sorting/trafficking of EGF receptor. Isoform 2 prevents stress-mediated cell death and accumulation of reactive oxygen species when expressed in yeast cells