Serine-threonine kinase receptor-associated protein (MAP activator with WD repeats) (UNR-interacting protein) (WD-40 repeat protein PT-WD)
1_MAMRQ 6_ TPLTC 11_ SGHTR 16_ PVVDL 21_ AFSGI 26_ TPYGY 31_ FLISA 36_ CKDGK 41_ PMLRQ 46_ GDTGD 51_ WIGTF 56_ LGHKG 61_ AVWGA 66_ TLNKD 71_ ATKAA 76_ TAAAD 81_ FTAKV 86_ WDAVS 91_ GDELM 96_ TLAHK 101_ HIVKT 106_ VDFTQ 111_ DSNYL 116_ LTGGQ 121_ DKLLR 126_ IYDLN 131_ KPEAE 136_ PKEIS 141_ GHTSG 146_ IKKAL 151_ WCSED 156_ KQILS 161_ ADDKT 166_ VRLWD 171_ HATMT 176_ EVKSL 181_ NFNMS 186_ VSSME 191_ YIPEG 196_ EILVI 201_ TYGRS 206_ IAFHS 211_ AVSLD 216_ PIKSF 221_ EAPAT 226_ INSAS 231_ LHPEK 236_ EFLVA 241_ GGEDF 246_ KLYKY 251_ DYNSG 256_ EELES 261_ YKGHF 266_ GPIHC 271_ VRFSP 276_ DGELY 281_ ASGSE 286_ DGTLR 291_ LWQTV 296_ VGKTY 301_ GLWKC 306_ VLPEE 311_ DSGEL 316_ AKPKI 321_ GFPET 326_ TEEEL 331_ EEIAS 336_ ENSDC 341_IFPSA
1: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein