F-box only protein 7
1_MRLRV 6_ RLLKR 11_ TWPLE 16_ VPETE 21_ PTLGH 26_ LRSHL 31_ RQSLL 36_ CTWGY 41_ SSNTR 46_ FTITL 51_ NYKDP 56_ LTGDE 61_ ETLAS 66_ YGIVS 71_ GDLIC 76_ LILQD 81_ DIPAP 86_ NIPSS 91_ TDSEH 96_ SSLQN 101_ NEQPS 106_ LATSS 111_ NQTSM 116_ QDEQP 121_ SDSFQ 126_ GQAAQ 131_ SGVWN 136_ DDSML 141_ GPSQN 146_ FEAES 151_ IQDNA 156_ HMAEG 161_ TGFYP 166_ SEPML 171_ CSESV 176_ EGQVP 181_ HSLET 186_ LYQSA 191_ DCSDA 196_ NDALI 201_ VLIHL 206_ LMLES 211_ GYIPQ 216_ GTEAK 221_ ALSMP 226_ EKWKL 231_ SGVYK 236_ LQYMH 241_ PLCEG 246_ SSATL 251_ TCVPL 256_ GNLIV 261_ VNATL 266_ KINNE 271_ IRSVK 276_ RLQLL 281_ PESFI 286_ CKEKL 291_ GENVA 296_ NIYKD 301_ LQKLS 306_ RLFKD 311_ QLVYP 316_ LLAFT 321_ RQALN 326_ LPDVF 331_ GLVVL 336_ PLELK 341_ LRIFR 346_ LLDVR 351_ SVLSL 356_ SAVCR 361_ DLFTA 366_ SNDPL 371_ LWRFL 376_ YLRDF 381_ RDNTV 386_ RVQDT 391_ DWKEL 396_ YRKRH 401_ IQRKE 406_ SPKGR 411_ FVMLL 416_ PSSTH 421_ TIPFY 426_ PNPLH 431_ PRPFP 436_ SSRLP 441_ PGIIG 446_ GEYDQ 451_ RPTLP 456_ YVGDP 461_ ISSLI 466_ PGPGE 471_ TPSQF 476_ PPLRP 481_ RFDPV 486_ GPLPG 491_ PNPIL 496_ PGRGG 501_ PNDRF 506_ PFRPS 511_ RGRPT 516_DGRLS
1: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability (PubMed:15145941, PubMed:34791250). Recognizes and ubiquitinates BIRC2 and the cell cycle regulator DLGAP5 (PubMed:15145941, PubMed:16510124, PubMed:22212761). Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination. Mediates the ubiquitination and proteasomal degradation of UXT isoform 2, thereby impairing the NF-kappa-B signaling pathway (PubMed:33010352). Inhibits NF-kappa-B pathway also by promoting the ubiquitination of TRAF2 (PubMed:22212761). Affects the assembly state and activity of the proteasome in the cells including neurons by ubiquitinating the proteasomal subunit PSMA2 via 'Lys-63'-linked polyubiquitin chains (By similarity). Promotes 'Lys-48'-linked polyubiquitination SIRT7, leading to the hydrogen peroxide-induced cell death (PubMed:36646384)