Gene name: SIT1

Uniprot entry:

Q9Y3P8

Protein names:

Signaling threshold-regulating transmembrane adapter 1 (SHP2-interacting transmembrane adapter protein) (Suppression-inducing transmembrane adapter 1) (gp30/40)

Protein sequence:

1_MNQAD 6_ PRLRA 11_ VCLWT 16_ LTSAA 21_ MSRGD 26_ NCTDL 31_ LALGI 36_ PSITQ 41_ AWGLW 46_ VLLGA 51_ VTLLF 56_ LISLA 61_ AHLSQ 66_ WTRGR 71_ SRSHP 76_ GQGRS 81_ GESVE 86_ EVPLY 91_ GNLHY 96_ LQTGR 101_ LSQDP 106_ EPDQQ 111_ DPTLG 116_ GPARA 121_ AEEVM 126_ CYTSL 131_ QLRPP 136_ QGRIP 141_ GPGTP 146_ VKYSE 151_ VVLDS 156_ EPKSQ 161_ ASGPE 166_ PELYA 171_ SVCAQ 176_ TRRAR 181_ ASFPD 186_ QAYAN 191_SQPAA

Protein annotations

Protein functions:

1: Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells. Involved in positive selection of T-cells