TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) (Tsc-22-like protein THG-1)
1_MSGGK 6_ KKSSF 11_ QITSV 16_ TTDYE 21_ GPGSP 26_ GASDP 31_ PTPQP 36_ PTGPP 41_ PRLPN 46_ GEPSP 51_ DPGGK 56_ GTPRN 61_ GSPPP 66_ GAPSS 71_ RFRVV 76_ KLPHG 81_ LGEPY 86_ RRGRW 91_ TCVDV 96_ YERDL 101_ EPHSF 106_ GGLLE 111_ GIRGA 116_ SGGAG 121_ GRSLD 126_ SRLEL 131_ ASLGL 136_ GAPTP 141_ PSGLS 146_ QGPTS 151_ WLRPP 156_ PTSPG 161_ PQARS 166_ FTGGL 171_ GQLVV 176_ PSKAK 181_ AEKPP 186_ LSASS 191_ PQQRP 196_ PEPET 201_ GESAG 206_ TSRAA 211_ TPLPS 216_ LRVEA 221_ EAGGS 226_ GARTP 231_ PLSRR 236_ KAVDM 241_ RLRME 246_ LGAPE 251_ EMGQV 256_ PPLDS 261_ RPSSP 266_ ALYFT 271_ HDASL 276_ VHKSP 281_ DPFGA 286_ VAAQK 291_ FSLAH 296_ SMLAI 301_ SGHLD 306_ SDDDS 311_ GSGSL 316_ VGIDN 321_ KIEQA 326_ MDLVK 331_ SHLMF 336_ AVREE 341_ VEVLK 346_ EQIRE 351_ LAERN 356_ AALEQ 361_ ENGLL 366_ RALAS 371_ PEQLA 376_ QLPSS 381_ GVPRL 386_GPPAP
1: Binds DNA and acts as a transcriptional repressor (PubMed:10488076). Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13 (By similarity). Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low-density lipoprotein release (PubMed:23307490). May play a role in neurite elongation and survival (By similarity)