Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43)
1_MDGDG 6_ GRRDV 11_ PGTLM 16_ EPGRG 21_ AGPAG 26_ MAEPR 31_ AKAAR 36_ PGPQR 41_ FLRRS 46_ VVESD 51_ QEEPP 56_ GLEAA 61_ EAPGP 66_ QPPQP 71_ LQRRV 76_ LLLCK 81_ TRRLI 86_ AERAR 91_ GRPAA 96_ PAPAA 101_ LVAQP 106_ GAPGA 111_ PADAG 116_ PEPVG 121_ TQEPG 126_ PDPIA 131_ AAVET 136_ APAPD 141_ GGPRE 146_ EAAAT 151_ VRKED 156_ EGAAE 161_ AKPEP 166_ GRTRR 171_ DEPEE 176_ EEDDE 181_ DDLKA 186_ VATSL 191_ DGRFL 196_ KFDIE 201_ LGRGS 206_ FKTVY 211_ KGLDT 216_ ETWVE 221_ VAWCE 226_ LQDRK 231_ LTKLE 236_ RQRFK 241_ EEAEM 246_ LKGLQ 251_ HPNIV 256_ RFYDF 261_ WESSA 266_ KGKRC 271_ IVLVT 276_ ELMTS 281_ GTLKT 286_ YLKRF 291_ KVMKP 296_ KVLRS 301_ WCRQI 306_ LKGLL 311_ FLHTR 316_ TPPII 321_ HRDLK 326_ CDNIF 331_ ITGPT 336_ GSVKI 341_ GDLGL 346_ ATLKR 351_ ASFAK 356_ SVIGT 361_ PEFMA 366_ PEMYE 371_ EHYDE 376_ SVDVY 381_ AFGMC 386_ MLEMA 391_ TSEYP 396_ YSECQ 401_ NAAQI 406_ YRKVT 411_ CGIKP 416_ ASFEK 421_ VHDPE 426_ IKEII 431_ GECIC 436_ KNKEE 441_ RYEIK 446_ DLLSH 451_ AFFAE 456_ DTGVR 461_ VELAE 466_ EDHGR 471_ KSTIA 476_ LRLWV 481_ EDPKK 486_ LKGKP 491_ KDNGA 496_ IEFTF 501_ DLEKE 506_ TPDEV 511_ AQEMI 516_ ESGFF 521_ HESDV 526_ KIVAK 531_ SIRDR 536_ VALIQ 541_ WRRER 546_ IWPAL 551_ QPKEQ 556_ QDVGS 561_ PDKAR 566_ GPPVP 571_ LQVQV 576_ TYHAQ 581_ AGQPG 586_ PPEPE 591_ EPEAD 596_ QHLLP 601_ PTLPT 606_ SATSL 611_ ASDST 616_ FDSGQ 621_ GSTVY 626_ SDSQS 631_ SQQSV 636_ MLGSL 641_ ADAAP 646_ SPAQC 651_ VCSPP 656_ VSEGP 661_ VLPQS 666_ LPSLG 671_ AYQQP 676_ TAAPG 681_ LPVGS 686_ VPAPA 691_ CPPSL 696_ QQHFP 701_ DPAMS 706_ FAPVL 711_ PPPST 716_ PMPTG 721_ PGQPA 726_ PPGQQ 731_ PPPLA 736_ QPTPL 741_ PQVLA 746_ PQPVV 751_ PLQPV 756_ PPHLP 761_ PYLAP 766_ ASQVG 771_ APAQL 776_ KPLQM 781_ PQAPL 786_ QPLAQ 791_ VPPQM 796_ PPIPV 801_ VPPIT 806_ PLAGI 811_ DGLPP 816_ ALPDL 821_ PTATV 826_ PPVPP 831_ PQYFS 836_ PAVIL 841_ PSLAA 846_ PLPPA 851_ SPALP 856_ LQAVK 861_ LPHPP 866_ GAPLA 871_ MPCRT 876_ IVPNA 881_ PATIP 886_ LLAVA 891_ PPGVA 896_ ALSIH 901_ SAVAQ 906_ LPGQP 911_ VYPAA 916_ FPQMA 921_ PTDVP 926_ PSPHH 931_ TVQNM 936_ RATPP 941_ QPALP 946_ PQPTL 951_ PPQPV 956_ LPPQP 961_ TLPPQ 966_ PVLPP 971_ QPTRP 976_ PQPVL 981_ PPQPM 986_ LPPQP 991_ VLPPQ 996_ PALPV 1001_ RPEPL 1006_ QPHLP 1011_ EQAAP 1016_ AATPG 1021_ SQILL 1026_ GHPAP 1031_ YAVDV 1036_ AAQVP 1041_ TVPVP 1046_ PAAVL 1051_ SPPLP 1056_ EVLLP 1061_ AAPEL 1066_ LPQFP 1071_ SSLAT 1076_ VSASV 1081_ QSVPT 1086_ QTATL 1091_ LPPAN 1096_ PPLPG 1101_ GPGIA 1106_ SPCPT 1111_ VQLTV 1116_ EPVQE 1121_ EQASQ 1126_ DKPPG 1131_ LPQSC 1136_ ESYGG 1141_ SDVTS 1146_ GKELS 1151_ DSCEG 1156_ AFGGG 1161_ RLEGR 1166_ AARKH 1171_ HRRST 1176_ RARSR 1181_ QERAS 1186_ RPRLT 1191_ ILNVC 1196_ NTGDK 1201_ MVECQ 1206_ LETHN 1211_ HKMVT 1216_ FKFDL 1221_ DGDAP 1226_ DEIAT 1231_ YMVEH 1236_ DFILQ 1241_ AERET 1246_ FIEQM 1251_ KDVMD 1256_ KAEDM 1261_ LSEDT 1266_ DADRG 1271_ SDPGT 1276_ SPPHL 1281_ STCGL 1286_ GTGEE 1291_ SRQSQ 1296_ ANAPV 1301_ YQQNV 1306_ LHTGK 1311_ RWFII 1316_ CPVAE 1321_ HPAPE 1326_ APESS 1331_ PPLPL 1336_ SSLPP 1341_ EASQG 1346_ PCRGL 1351_ TLPCL 1356_ PWRRA 1361_ ACGAV 1366_ FLSLF 1371_ SAESA 1376_ QSKQP 1381_ PDSAP 1386_ YKDQL 1391_ SSKEQ 1396_ PSFLA 1401_ SQQLL 1406_ SQAGP 1411_ SNPPG 1416_ APPAP 1421_ LAPSS 1426_ PPVTA 1431_ LPQDG 1436_ AAPAT 1441_ STMPE 1446_ PASGT 1451_ ASQAG 1456_ GPGTP 1461_ QGLTS 1466_ ELETS 1471_ QPLAE 1476_ THEAP 1481_ LAVQP 1486_ LVVGL 1491_ APCTP 1496_ APEAA 1501_ STRDA 1506_ SAPRE 1511_ PLPPP 1516_ APEPS 1521_ PHSGT 1526_ PQPAL 1531_ GQPAP 1536_ LLPAA 1541_ VGAVS 1546_ LATSQ 1551_ LPSPP 1556_ LGPTV 1561_ PPQPP 1566_ SALES 1571_ DGEGP 1576_ PPRVG 1581_ FVDST 1586_ IKSLD 1591_ EKLRT 1596_ LLYQE 1601_ HVPTS 1606_ SASAG 1611_ TPVEV 1616_ GDRDF 1621_ TLEPL 1626_ RGDQP 1631_ RSEVC 1636_ GGDLA 1641_ LPPVP 1646_ KEAVS 1651_ GRVQL 1656_ PQPLV 1661_ EKSEL 1666_ APTRG 1671_ AVMEQ 1676_ GTSSS 1681_ MTAES 1686_ SPRSM 1691_ LGYDR 1696_ DGRQV 1701_ ASDSH 1706_ VVPSV 1711_ PQDVP 1716_ AFVRP 1721_ ARVEP 1726_ TDRDG 1731_ GEAGE 1736_ SSAEP 1741_ PPSDM 1746_ GTVGG 1751_ QASHP 1756_ QTLGA 1761_ RALGS 1766_ PRKRP 1771_ EQQDV 1776_ SSPAK 1781_ TVGRF 1786_ SVVST 1791_ QDEWT 1796_ LASPH 1801_ SLRYS 1806_ APPDV 1811_ YLDEA 1816_ PSSPD 1821_ VKLAV 1826_ RRAQT 1831_ ASSIE 1836_ VGVGE 1841_ PVSSD 1846_ SGDEG 1851_ PRARP 1856_ PVQKQ 1861_ ASLPV 1866_ SGSVA 1871_ GDFVK 1876_ KATAF 1881_ LQRPS 1886_ RAGSL 1891_ GPETP 1896_ SRVGM 1901_ KVPTI 1906_ SVTSF 1911_ HSQSS 1916_ YISSD 1921_ NDSEL 1926_ EDADI 1931_ KKELQ 1936_ SLREK 1941_ HLKEI 1946_ SELQS 1951_ QQKQE 1956_ IEALY 1961_ RRLGK 1966_ PLPPN 1971_ VGFFH 1976_ TAPPT 1981_ GRRRK 1986_ TSKSK 1991_ LKAGK 1996_ LLNPL 2001_ VRQLK 2006_ VVASS 2011_ TGHLA 2016_ DSSRG 2021_ PPAKD 2026_ PAQAS 2031_ VGLTA 2036_ DSTGL 2041_ SGKAV 2046_ QTQQP 2051_ CSVRA 2056_ SLSSD 2061_ ICSGL 2066_ ASDGG 2071_ GARGQ 2076_ GWTVY 2081_ HPTSE 2086_ RVTYK 2091_ SSSKP 2096_ RARFL 2101_ SGPVS 2106_ VSIWS 2111_ ALKRL 2116_ CLGKE 2121_ HSSRS 2126_ STSSL 2131_ APGPE 2136_ PGPQP 2141_ ALHVQ 2146_ AQVNN 2151_ SNNKK 2156_ GTFTD 2161_ DLHKL 2166_ VDEWT 2171_ SKTVG 2176_ AAQLK 2181_ PTLNQ 2186_ LKQTQ 2191_ KLQDM 2196_ EAQAG 2201_ WAAPG 2206_ EARAM 2211_ TAPRA 2216_ GVGMP 2221_ RLPPA 2226_ PGPLS 2231_ TTVIP 2236_ GAAPT 2241_ LSVPT 2246_ PDGAL 2251_ GTARR 2256_ NQVWF 2261_ GLRVP 2266_ PTACC 2271_ GHSTQ 2276_ PRGGQ 2281_ RVGSK 2286_ TASFA 2291_ASDPV
1: Serine/threonine-protein kinase component of the WNK2-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation (PubMed:17667937, PubMed:18593598, PubMed:21733846). The WNK2-SPAK/OSR1 kinase cascade is composed of WNK2, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (By similarity). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, regulating their activity (By similarity). Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:21733846). Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5 (PubMed:21733846). Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression (PubMed:17667937, PubMed:18593598). Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1 (PubMed:17667937, PubMed:18593598). WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity (PubMed:17667937, PubMed:18593598)