Nucleolar complex protein 2 homolog (Protein NOC2 homolog) (NOC2-like protein) (Novel INHAT repressor)
1_MAAAG 6_ SRKRR 11_ LAELT 16_ VDEFL 21_ ASGFD 26_ SESES 31_ ESENS 36_ PQAET 41_ REARE 46_ AARSP 51_ DKPGG 56_ SPSAS 61_ RRKGR 66_ ASEHK 71_ DQLSR 76_ LKDRD 81_ PEFYK 86_ FLQEN 91_ DQSLL 96_ NFSDS 101_ DSSEE 106_ EEGPF 111_ HSLPD 116_ VLEEA 121_ SEEED 126_ GAEEG 131_ EDGDR 136_ VPRGL 141_ KGKKN 146_ SVPVT 151_ VAMVE 156_ RWKQA 161_ AKQRL 166_ TPKLF 171_ HEVVQ 176_ AFRAA 181_ VATTR 186_ GDQES 191_ AEANK 196_ FQVTD 201_ SAAFN 206_ ALVTF 211_ CIRDL 216_ IGCLQ 221_ KLLFG 226_ KVAKD 231_ SSRML 236_ QPSSS 241_ PLWGK 246_ LRVDI 251_ KAYLG 256_ SAIQL 261_ VSCLS 266_ ETTVL 271_ AAVLR 276_ HISVL 281_ VPCFL 286_ TFPKQ 291_ CRMLL 296_ KRMVI 301_ VWSTG 306_ EESLR 311_ VLAFL 316_ VLSRV 321_ CRHKK 326_ DTFLG 331_ PVLKQ 336_ MYITY 341_ VRNCK 346_ FTSPG 351_ ALPFI 356_ SFMQW 361_ TLTEL 366_ LALEP 371_ GVAYQ 376_ HAFLY 381_ IRQLA 386_ IHLRN 391_ AMTTR 396_ KKETY 401_ QSVYN 406_ WQYVH 411_ CLFLW 416_ CRVLS 421_ TAGPS 426_ EALQP 431_ LVYPL 436_ AQVII 441_ GCIKL 446_ IPTAR 451_ FYPLR 456_ MHCIR 461_ ALTLL 466_ SGSSG 471_ AFIPV 476_ LPFIL 481_ EMFQQ 486_ VDFNR 491_ KPGRM 496_ SSKPI 501_ NFSVI 506_ LKLSN 511_ VNLQE 516_ KAYRD 521_ GLVEQ 526_ LYDLT 531_ LEYLH 536_ SQAHC 541_ IGFPE 546_ LVLPV 551_ VLQLK 556_ SFLRE 561_ CKVAN 566_ YCRQV 571_ QQLLG 576_ KVQEN 581_ SAYIC 586_ SRRQR 591_ VSFGV 596_ SEQQA 601_ VEAWE 606_ KLTRE 611_ EGTPL 616_ TLYYS 621_ HWRKL 626_ RDREI 631_ QLEIS 636_ GKERL 641_ EDLNF 646_ PEIKR 651_ RKMAD 656_ RKDED 661_ RKQFK 666_ DLFDL 671_ NSSEE 676_ DDTEG 681_ FSERG 686_ ILRPL 691_ STRHG 696_ VEDDE 701_ EDEEE 706_ GEEDS 711_ SNSED 716_ GDPDA 721_ EAGLA 726_ PGELQ 731_ QLAQG 736_ PEDEL 741_EDLQL
1: Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter