Chromatin target of PRMT1 protein (Friend of PRMT1 protein) (Small arginine- and glycine-rich protein) (SRAG)
1_MAAQS 6_ APKVV 11_ LKSTT 16_ KMSLN 21_ ERFTN 26_ MLKNK 31_ QPTPV 36_ NIRAS 41_ MQQQQ 46_ QLASA 51_ RNRRL 56_ AQQME 61_ NRPSV 66_ QAALK 71_ LKQSL 76_ KQRLG 81_ KSNIQ 86_ ARLGR 91_ PIGAL 96_ ARGAI 101_ GGRGL 106_ PIIQR 111_ GLPRG 116_ GLRGG 121_ RATRT 126_ LLRGG 131_ MSLRG 136_ QNLLR 141_ GGRAV 146_ APRMG 151_ LRRGG 156_ VRGRG 161_ GPGRG 166_ GLGRG 171_ AMGRG 176_ GIGGR 181_ GRGMI 186_ GRGRG 191_ GFGGR 196_ GRGRG 201_ RGRGA 206_ LARPV 211_ LTKEQ 216_ LDNQL 221_ DAYMS 226_ KTKGH 231_ LDAEL 236_ DAYMA 241_QTDPE
1: Plays an important role in the ligand-dependent activation of estrogen receptor target genes (PubMed:19858291). May play a role in the silencing of fetal globin genes (PubMed:20688955). Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (By similarity). Plays an important role in the tumorigenicity of glioblastoma cells. Binds to 5-hydroxymethylcytosine (5hmC) and associates with the methylosome complex containing PRMT1, PRMT5, MEP50 and ERH. The CHTOP-methylosome complex associated with 5hmC is recruited to selective sites on the chromosome, where it methylates H4R3 and activates the transcription of genes involved in glioblastomagenesis (PubMed:25284789)
2: Required for effective mRNA nuclear export and is a component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Stimulates DDX39B ATPase and helicase activities. In cooperation with ALYREF/THOC4 enhances NXF1 RNA binding activity (PubMed:23299939)