Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) (Dendritic cell-derived IFNG-induced protein) (DCIP) (Monocyte protein 5) (MOP-5) (SAM domain and HD domain-containing protein 1) (hSAMHD1)
1_MQRAD 6_ SEQPS 11_ KRPRC 16_ DDSPR 21_ TPSNT 26_ PSAEA 31_ DWSPG 36_ LELHP 41_ DYKTW 46_ GPEQV 51_ CSFLR 56_ RGGFE 61_ EPVLL 66_ KNIRE 71_ NEITG 76_ ALLPC 81_ LDESR 86_ FENLG 91_ VSSLG 96_ ERKKL 101_ LSYIQ 106_ RLVQI 111_ HVDTM 116_ KVIND 121_ PIHGH 126_ IELHP 131_ LLVRI 136_ IDTPQ 141_ FQRLR 146_ YIKQL 151_ GGGYY 156_ VFPGA 161_ SHNRF 166_ EHSLG 171_ VGYLA 176_ GCLVH 181_ ALGEK 186_ QPELQ 191_ ISERD 196_ VLCVQ 201_ IAGLC 206_ HDLGH 211_ GPFSH 216_ MFDGR 221_ FIPLA 226_ RPEVK 231_ WTHEQ 236_ GSVMM 241_ FEHLI 246_ NSNGI 251_ KPVME 256_ QYGLI 261_ PEEDI 266_ CFIKE 271_ QIVGP 276_ LESPV 281_ EDSLW 286_ PYKGR 291_ PENKS 296_ FLYEI 301_ VSNKR 306_ NGIDV 311_ DKWDY 316_ FARDC 321_ HHLGI 326_ QNNFD 331_ YKRFI 336_ KFARV 341_ CEVDN 346_ ELRIC 351_ ARDKE 356_ VGNLY 361_ DMFHT 366_ RNSLH 371_ RRAYQ 376_ HKVGN 381_ IIDTM 386_ ITDAF 391_ LKADD 396_ YIEIT 401_ GAGGK 406_ KYRIS 411_ TAIDD 416_ MEAYT 421_ KLTDN 426_ IFLEI 431_ LYSTD 436_ PKLKD 441_ AREIL 446_ KQIEY 451_ RNLFK 456_ YVGET 461_ QPTGQ 466_ IKIKR 471_ EDYES 476_ LPKEV 481_ ASAKP 486_ KVLLD 491_ VKLKA 496_ EDFIV 501_ DVINM 506_ DYGMQ 511_ EKNPI 516_ DHVSF 521_ YCKTA 526_ PNRAI 531_ RITKN 536_ QVSQL 541_ LPEKF 546_ AEQLI 551_ RVYCK 556_ KVDRK 561_ SLYAA 566_ RQYFV 571_ QWCAD 576_ RNFTK 581_ PQDGD 586_ VIAPL 591_ ITPQK 596_ KEWND 601_ STSVQ 606_ NPTRL 611_ REASK 616_ SRVQL 621_FKDDP
1: Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks (PubMed:19525956, PubMed:21613998, PubMed:21720370, PubMed:22056990, PubMed:23601106, PubMed:23602554, PubMed:24336198, PubMed:26294762, PubMed:26431200, PubMed:28229507, PubMed:28834754, PubMed:29670289). Has deoxynucleoside triphosphate (dNTPase) activity, which is required to restrict infection by viruses, such as HIV-1: dNTPase activity reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur, blocking early-stage virus replication in dendritic and other myeloid cells (PubMed:19525956, PubMed:21613998, PubMed:21720370, PubMed:22056990, PubMed:23364794, PubMed:23601106, PubMed:23602554, PubMed:24336198, PubMed:25038827, PubMed:26101257, PubMed:26294762, PubMed:26431200, PubMed:28229507). Likewise, suppresses LINE-1 retrotransposon activity (PubMed:24035396, PubMed:24217394, PubMed:29610582). Not able to restrict infection by HIV-2 virus; because restriction activity is counteracted by HIV-2 viral protein Vpx (PubMed:21613998, PubMed:21720370). In addition to virus restriction, dNTPase activity acts as a regulator of DNA precursor pools by regulating dNTP pools (PubMed:23858451). Phosphorylation at Thr-592 acts as a switch to control dNTPase-dependent and -independent functions: it inhibits dNTPase activity and ability to restrict infection by viruses, while it promotes DNA end resection at stalled replication forks (PubMed:23601106, PubMed:23602554, PubMed:29610582, PubMed:29670289). Functions during S phase at stalled DNA replication forks to promote the resection of gapped or reversed forks: acts by stimulating the exonuclease activity of MRE11, activating the ATR-CHK1 pathway and allowing the forks to restart replication (PubMed:29670289). Its ability to promote degradation of nascent DNA at stalled replication forks is required to prevent induction of type I interferons, thereby preventing chronic inflammation (PubMed:27477283, PubMed:29670289). Ability to promote DNA end resection at stalled replication forks is independent of dNTPase activity (PubMed:29670289). Enhances immunoglobulin hypermutation in B-lymphocytes by promoting transversion mutation (By similarity)