Small kinetochore-associated protein (SKAP) (Kinetochore-localized astrin-binding protein) (Kinastrin) (Kinetochore-localized astrin/SPAG5-binding protein) (TRAF4-associated factor 1)
1_MAAPE 6_ APPLD 11_ RVFRT 16_ TWLST 21_ ECDSH 26_ PLPPS 31_ YRKFL 36_ FETQA 41_ ADLAG 46_ GTTVA 51_ AGNLL 56_ NESEK 61_ DCGQD 66_ RRAPG 71_ VQPCR 76_ LVTMT 81_ SVVKT 86_ VYSLQ 91_ PPSAL 96_ SGGQP 101_ ADTQT 106_ RATSK 111_ SLLPV 116_ RSKEV 121_ DVSKQ 126_ LHSGG 131_ PENDV 136_ TKITK 141_ LRREN 146_ GQMKA 151_ TDTAT 156_ RRNVR 161_ KGYKP 166_ LSKQK 171_ SEEEL 176_ KDKNQ 181_ LLEAV 186_ NKQLH 191_ QKLTE 196_ TQGEL 201_ KDLTQ 206_ KVELL 211_ EKFRD 216_ NCLAI 221_ LESKG 226_ LDPAL 231_ GSETL 236_ ASRQE 241_ STTDH 246_ MDSML 251_ LLETL 256_ QEELK 261_ LFNET 266_ AKKQM 271_ EELQA 276_ LKVKL 281_ EMKEE 286_ RVRFL 291_ EQQTL 296_ CNNQV 301_ NDLTT 306_ ALKEM 311_EQLLE
1: Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase (PubMed:19667759). Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:19667759, PubMed:22110139). The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments (PubMed:21402792). Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division (PubMed:23035123). May be involved in UV-induced apoptosis via its interaction with PRPF19; however, these results need additional evidences (PubMed:24718257)