HBS1-like protein (ERFS)
1_MARHR 6_ NVRGY 11_ NYDED 16_ FEDDD 21_ LYGQS 26_ VEDDY 31_ CISPS 36_ TAAQF 41_ IYSRR 46_ DKPSV 51_ EPVEE 56_ YDYED 61_ LKESS 66_ NSVSN 71_ HQLSG 76_ FDQAR 81_ LYSCL 86_ DHMRE 91_ VLGDA 96_ VPDEI 101_ LIEAV 106_ LKNKF 111_ DVQKA 116_ LSGVL 121_ EQDRV 126_ QSLKD 131_ KNEAT 136_ VSTGK 141_ IAKGK 146_ PVDSQ 151_ TSRSE 156_ SEIVP 161_ KVAKM 166_ TVSGK 171_ KQTMG 176_ FEVPG 181_ VSSEE 186_ NGHSF 191_ HTPQK 196_ GPPIE 201_ DAIAS 206_ SDVLE 211_ TASKS 216_ ANPPH 221_ TIQAS 226_ EEQSS 231_ TPAPV 236_ KKSGK 241_ LRQQI 246_ DVKAE 251_ LEKRQ 256_ GGKQL 261_ LNLVV 266_ IGHVD 271_ AGKST 276_ LMGHM 281_ LYLLG 286_ NINKR 291_ TMHKY 296_ EQESK 301_ KAGKA 306_ SFAYA 311_ WVLDE 316_ TGEER 321_ ERGVT 326_ MDVGM 331_ TKFET 336_ TTKVI 341_ TLMDA 346_ PGHKD 351_ FIPNM 356_ ITGAA 361_ QADVA 366_ VLVVD 371_ ASRGE 376_ FEAGF 381_ ETGGQ 386_ TREHG 391_ LLVRS 396_ LGVTQ 401_ LAVAV 406_ NKMDQ 411_ VNWQQ 416_ ERFQE 421_ ITGKL 426_ GHFLK 431_ QAGFK 436_ ESDVG 441_ FIPTS 446_ GLSGE 451_ NLITR 456_ SQSSE 461_ LTKWY 466_ KGLCL 471_ LEQID 476_ SFKPP 481_ QRSID 486_ KPFRL 491_ CVSDV 496_ FKDQG 501_ SGFCI 506_ TGKIE 511_ AGYIQ 516_ TGDRL 521_ LAMPP 526_ NETCT 531_ VKGIT 536_ LHDEP 541_ VDWAA 546_ AGDHV 551_ SLTLV 556_ GMDII 561_ KINVG 566_ CIFCG 571_ PKVPI 576_ KACTR 581_ FRARI 586_ LIFNI 591_ EIPIT 596_ KGFPV 601_ LLHYQ 606_ TVSEP 611_ AVIKR 616_ LISVL 621_ NKSTG 626_ EVTKK 631_ KPKFL 636_ TKGQN 641_ ALVEL 646_ QTQRP 651_ IALEL 656_ YKDFK 661_ ELGRF 666_ MLRYG 671_ GSTIA 676_AGVVT
1: GTPase component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:21448132, PubMed:23667253, PubMed:27863242). The Pelota-HBS1L complex recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel (PubMed:27863242). Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:21448132, PubMed:32006463)