Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1) (Minibrain-related kinase) (Mirk protein kinase)
1_MAVPP 6_ GHGPF 11_ SGFPG 16_ PQEHT 21_ QVLPD 26_ VRLLP 31_ RRLPL 36_ AFRDA 41_ TSAPL 46_ RKLSV 51_ DLIKT 56_ YKHIN 61_ EVYYA 66_ KKKRR 71_ AQQAP 76_ PQDSS 81_ NKKEK 86_ KVLNH 91_ GYDDD 96_ NHDYI 101_ VRSGE 106_ RWLER 111_ YEIDS 116_ LIGKG 121_ SFGQV 126_ VKAYD 131_ HQTQE 136_ LVAIK 141_ IIKNK 146_ KAFLN 151_ QAQIE 156_ LRLLE 161_ LMNQH 166_ DTEMK 171_ YYIVH 176_ LKRHF 181_ MFRNH 186_ LCLVF 191_ ELLSY 196_ NLYDL 201_ LRNTH 206_ FRGVS 211_ LNLTR 216_ KLAQQ 221_ LCTAL 226_ LFLAT 231_ PELSI 236_ IHCDL 241_ KPENI 246_ LLCNP 251_ KRSAI 256_ KIVDF 261_ GSSCQ 266_ LGQRI 271_ YQYIQ 276_ SRFYR 281_ SPEVL 286_ LGTPY 291_ DLAID 296_ MWSLG 301_ CILVE 306_ MHTGE 311_ PLFSG 316_ SNEVD 321_ QMNRI 326_ VEVLG 331_ IPPAA 336_ MLDQA 341_ PKARK 346_ YFERL 351_ PGGGW 356_ TLRRT 361_ KELRK 366_ DYQGP 371_ GTRRL 376_ QEVLG 381_ VQTGG 386_ PGGRR 391_ AGEPG 396_ HSPAD 401_ YLRFQ 406_ DLVLR 411_ MLEYE 416_ PAARI 421_ SPLGA 426_ LQHGF 431_ FRRTA 436_ DEATN 441_ TGPAG 446_ SSAST 451_ SPAPL 456_ DTCPS 461_ SSTAS 466_ SISSS 471_ GGSSG 476_ SSSDN 481_ RTYRY 486_ SNRYC 491_ GGPGP 496_ PITDC 501_ EMNSP 506_ QVPPS 511_ QPLRP 516_ WAGGD 521_ VPHKT 526_ HQAPA 531_ SASSL 536_ PGTGA 541_ QLPPQ 546_ PRYLG 551_ RPPSP 556_ TSPPP 561_ PELMD 566_ VSLVG 571_ GPADC 576_ SPPHP 581_ APAPQ 586_ HPAAS 591_ ALRTR 596_ MTGGR 601_ PPLPP 606_ PDDPA 611_ TLGPH 616_ LGLRG 621_VPQST
1: Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Plays an essential role in ribosomal DNA (rDNA) double-strand break repair and rDNA copy number maintenance (PubMed:33469661). During DNA damage, mediates transcription silencing in part via phosphorylating and enforcing DSB accumulation of the histone methyltransferase EHMT2 (PubMed:32611815). Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase catalytic subunit 1 (G6PC1)