Nuclear receptor subfamily 2 group E member 1 (Nuclear receptor TLX) (Protein tailless homolog) (Tll) (hTll)
1_MSKPA 6_ GSTSR 11_ ILDIP 16_ CKVCG 21_ DRSSG 26_ KHYGV 31_ YACDG 36_ CSGFF 41_ KRSIR 46_ RNRTY 51_ VCKSG 56_ NQGGC 61_ PVDKT 66_ HRNQC 71_ RACRL 76_ KKCLE 81_ VNMNK 86_ DAVQH 91_ ERGPR 96_ TSTIR 101_ KQVAL 106_ YFRGH 111_ KEENG 116_ AAAHF 121_ PSAAL 126_ PAPAF 131_ FTAVT 136_ QLEPH 141_ GLELA 146_ AVSTT 151_ PERQT 156_ LVSLA 161_ QPTPK 166_ YPHEV 171_ NGTPM 176_ YLYEV 181_ ATESV 186_ CESAA 191_ RLLFM 196_ SIKWA 201_ KSVPA 206_ FSTLS 211_ LQDQL 216_ MLLED 221_ AWREL 226_ FVLGI 231_ AQWAI 236_ PVDAN 241_ TLLAV 246_ SGMNG 251_ DNTDS 256_ QKLNK 261_ IISEI 266_ QALQE 271_ VVARF 276_ RQLRL 281_ DATEF 286_ ACLKC 291_ IVTFK 296_ AVPTH 301_ SGSEL 306_ RSFRN 311_ AAAIA 316_ ALQDE 321_ AQLTL 326_ NSYIH 331_ TRYPT 336_ QPCRF 341_ GKLLL 346_ LLPAL 351_ RSISP 356_ STIEE 361_ VFFKK 366_ TIGNV 371_ PITRL 376_LSDMY
1: Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity). May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity (By similarity). May be involved in retinoic acid receptor (RAR) regulation in retinal cells