Lethal(3)malignant brain tumor-like protein 1 (H-l(3)mbt) (H-l(3)mbt protein) (L(3)mbt-like) (L(3)mbt protein homolog) (L3MBTL1)
1_MHLVA 6_ GDSPG 11_ SGPHL 16_ PATAF 21_ IIPAS 26_ SATLG 31_ LPSSA 36_ LDVSC 41_ FPREP 46_ IHVGA 51_ PEQVA 56_ GCEPV 61_ SATVL 66_ PQLSA 71_ GPASS 76_ STSTV 81_ RLLEW 86_ TEAAA 91_ PPPGG 96_ GLRFR 101_ ISEYK 106_ PLNMA 111_ GVEQP 116_ PSPEL 121_ RQEGV 126_ TEYED 131_ GGAPA 136_ GDGEA 141_ GPQQA 146_ EDHPQ 151_ NPPED 156_ PNQDP 161_ PEDDS 166_ TCQCQ 171_ ACGPH 176_ QAAGP 181_ DLGSS 186_ NDGCP 191_ QLFQE 196_ RSVIV 201_ ENSSG 206_ STSAS 211_ ELLKP 216_ MKKRK 221_ RREYQ 226_ SPSEE 231_ ESEPE 236_ AMEKQ 241_ EEGKD 246_ PEGQP 251_ TASTP 256_ ESEEW 261_ SSSQP 266_ ATGEK 271_ KECWS 276_ WESYL 281_ EEQKA 286_ ITAPV 291_ SLFQD 296_ SQAVT 301_ HNKNG 306_ FKLGM 311_ KLEGI 316_ DPQHP 321_ SMYFI 326_ LTVAE 331_ VCGYR 336_ LRLHF 341_ DGYSE 346_ CHDFW 351_ VNANS 356_ PDIHP 361_ AGWFE 366_ KTGHK 371_ LQPPK 376_ GYKEE 381_ EFSWS 386_ QYLRS 391_ TRAQA 396_ APKHL 401_ FVSQS 406_ HSPPP 411_ LGFQV 416_ GMKLE 421_ AVDRM 426_ NPSLV 431_ CVASV 436_ TDVVD 441_ SRFLV 446_ HFDNW 451_ DDTYD 456_ YWCDP 461_ SSPYI 466_ HPVGW 471_ CQKQG 476_ KPLTP 481_ PQDYP 486_ DPDNF 491_ CWEKY 496_ LEETG 501_ ASAVP 506_ TWAFK 511_ VRPPH 516_ SFLVN 521_ MKLEA 526_ VDRRN 531_ PALIR 536_ VASVE 541_ DVEDH 546_ RIKIH 551_ FDGWS 556_ HGYDF 561_ WIDAD 566_ HPDIH 571_ PAGWC 576_ SKTGH 581_ PLQPP 586_ LGPRE 591_ PSSAS 596_ PGGCP 601_ PLSYR 606_ SLPHT 611_ RTSKY 616_ SFHHR 621_ KCPTP 626_ GCDGS 631_ GHVTG 636_ KFTAH 641_ HCLSG 646_ CPLAE 651_ RNQSR 656_ LKAEL 661_ SDSEA 666_ SARKK 671_ NLSGF 676_ SPRKK 681_ PRHHG 686_ RIGRP 691_ PKYRK 696_ IPQED 701_ FQTLT 706_ PDVVH 711_ QSLFM 716_ SALSA 721_ HPDRS 726_ LSVCW 731_ EQHCK 736_ LLPGV 741_ AGISA 746_ STVAK 751_ WTIDE 756_ VFGFV 761_ QTLTG 766_ CEDQA 771_ RLFKD 776_ EARIV 781_ RVTHV 786_ SGKTL 791_ VWTVA 796_ QLGDL 801_ VCSDH 806_ LQEGK 811_ GILET 816_ GVHSL 821_ LCSLP 826_ THLLA 831_KLSFA
1: Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, thereby acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/H1-4 at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis