Inactive cytidine monophosphate-N-acetylneuraminic acid hydroxylase (CMP-NeuAc hydroxylase-like protein) (Cytidine monophosphate-N-acetylneuraminic acid hydroxylase pseudogene)
1_MDENN 6_ GLLLL 11_ ELNPP 16_ NPWDL 21_ QPRSP 26_ EELAF 31_ GEVQI 36_ TYLTH 41_ ACMDL 46_ KLGDK 51_ RMVFD 56_ PWLIG 61_ PAFAR 66_ GWWLL 71_ HEPPS 76_ DWLER 81_ LCQAD 86_ LIYIS 91_ HLHSD 96_ HLSYP 101_ TLKKL 106_ AGRRP 111_ DIPIY 116_ VGNTE 121_ RPVFW 126_ NLNQS 131_ GVQLT 136_ NINVV 141_ PFGIW 146_ QQVDK 151_ NLRFM 156_ ILMDG 161_ VHPEM 166_ DTCII 171_ VEYKG 176_ HKILN 181_ IVDCT 186_ RPNGG 191_ RLPMK 196_ VALMM 201_ SDFAG 206_ GASGF 211_ PMTFS 216_ GGKFT 221_ EEWKA 226_ QFIKT 231_ ERKKL 236_ LNYKA 241_ RLVKN 246_ LQPRI 251_ YCPFA 256_ GYFVE 261_ SHPSD 266_ KYIKE 271_ TNTKN 276_ DPNEL 281_ NNLIK 286_ KNSDV 291_ ITWTP 296_ RPGAT 301_ LDLGR 306_ MLKDR 311_ TDSKG 316_ IIEPP 321_ EGTKI 326_ YKDSW 331_ DFEPY 336_ LEILN 341_ AALGD 346_ EIFLH 351_ SSWIK 356_ EYFTW 361_ AGFKD 366_ YNLVV 371_ RMIET 376_ DEDFN 381_ PFPGG 386_ YDYLV 391_ DFLDL 396_ SFPKE 401_ RPQRE 406_ HPYEE 411_ IHSRV 416_ DVIRH 421_ VVKNG 426_ LLWDE 431_ LYIGF 436_ QTRLQ 441_ RDPDI 446_ YHHLF 451_ WNHFQ 456_ IKLPL 461_ TPPNW 466_ KSFLM 471_ CCEQN 476_ GPVIL 481_ QFSTE 486_ RTNEP 491_ NRNKF 496_SVENK
1: Sialic acids are components of carbohydrate chains of glycoconjugates and are involved in cell-cell recognition and cell-pathogen interactions. That protein has no CMP-N-acetylneuraminate monooxygenase activity and is not able to convert CMP-N-acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N-glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells in vertebrates (PubMed:9624188). However, it may play a role in Wnt signaling (PubMed:19890979)