5'-AMP-activated protein kinase subunit beta-1 (AMPK subunit beta-1) (AMPKb)
1_MGNTS 6_ SERAA 11_ LERHG 16_ GHKTP 21_ RRDSS 26_ GGTKD 31_ GDRPK 36_ ILMDS 41_ PEDAD 46_ LFHSE 51_ EIKAP 56_ EKEEF 61_ LAWQH 66_ DLEVN 71_ DKAPA 76_ QARPT 81_ VFRWT 86_ GGGKE 91_ VYLSG 96_ SFNNW 101_ SKLPL 106_ TRSHN 111_ NFVAI 116_ LDLPE 121_ GEHQY 126_ KFFVD 131_ GQWTH 136_ DPSEP 141_ IVTSQ 146_ LGTVN 151_ NIIQV 156_ KKTDF 161_ EVFDA 166_ LMVDS 171_ QKCSD 176_ VSELS 181_ SSPPG 186_ PYHQE 191_ PYVCK 196_ PEERF 201_ RAPPI 206_ LPPHL 211_ LQVIL 216_ NKDTG 221_ ISCDP 226_ ALLPE 231_ PNHVM 236_ LNHLY 241_ ALSIK 246_ DGVMV 251_ LSATH 256_ RYKKK 261_YVTTL
1: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3)