Metal-response element-binding transcription factor 2 (Metal regulatory transcription factor 2) (Metal-response element DNA-binding protein M96) (Polycomb-like protein 2) (hPCl2)
1_MRDST 6_ GAGNS 11_ LVHKR 16_ SPLRR 21_ NQKTP 26_ TSLTK 31_ LSLQD 36_ GHKAK 41_ KPACK 46_ FEEGQ 51_ DVLAR 56_ WSDGL 61_ FYLGT 66_ IKKIN 71_ ILKQS 76_ CFIIF 81_ EDSSK 86_ SWVLW 91_ KDIQT 96_ GATGS 101_ GEMVC 106_ TICQE 111_ EYSEA 116_ PNEMV 121_ ICDKC 126_ GQGYH 131_ QLCHT 136_ PHIDS 141_ SVIDS 146_ DEKWL 151_ CRQCV 156_ FATTT 161_ KRGGA 166_ LKKGP 171_ NAKAL 176_ QVMKQ 181_ TLPYS 186_ VADLE 191_ WDAGH 196_ KTNVQ 201_ QCYCY 206_ CGGPG 211_ DWYLK 216_ MLQCC 221_ KCKQW 226_ FHEAC 231_ VQCLQ 236_ KPMLF 241_ GDRFY 246_ TFICS 251_ VCSSG 256_ PEYLK 261_ RLPLQ 266_ WVDIA 271_ HLCLY 276_ NLSVI 281_ HKKKY 286_ FDSEL 291_ ELMTY 296_ INENW 301_ DRLHP 306_ GELAD 311_ TPKSE 316_ RYEHV 321_ LEALN 326_ DYKTM 331_ FMSGK 336_ EIKKK 341_ KHLFG 346_ LRIRV 351_ PPVPP 356_ NVAFK 361_ AEKEP 366_ EGTSH 371_ EFKIK 376_ GRKAS 381_ KPISD 386_ SREVS 391_ NGIEK 396_ KGKKK 401_ SVGRP 406_ PGPYT 411_ RKMIQ 416_ KTAEP 421_ LLDKE 426_ SISEN 431_ PTLDL 436_ PCSIG 441_ RTEGT 446_ AHSSN 451_ TSDVD 456_ FTGAS 461_ SAKET 466_ TSSSI 471_ SRHYG 476_ LSDSR 481_ KRTRT 486_ GRSWP 491_ AAIPH 496_ LRRRR 501_ GRLPR 506_ RALQT 511_ QNSEI 516_ VKDDE 521_ GKEDY 526_ QFDEL 531_ NTEIL 536_ NNLAD 541_ QELQL 546_ NHLKN 551_ SITSY 556_ FGAAG 561_ RIACG 566_ EKYRV 571_ LARRV 576_ TLDGK 581_ VQYLV 586_EWEGA
1: Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity (PubMed:23142980, PubMed:23228662, PubMed:31959557). Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation (By similarity). Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells (By similarity). Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex (By similarity). In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally (By similarity). Binds to the metal-regulating-element (MRE) of MT1A gene promoter (By similarity)